EXAM 4- Cholinesterase inhibitors

Question 1

dementia

Answer 1

Involves the decrease in cognitive function such as:
     memory
     attention
     language or communication
     problem solving skills

Question 2

impaired ACh neurotransmitter results in–

Answer 2

symptoms of dementia

Question 3

Cholinesterase inhibitors and N-methyl-D-asparate (NMDA)receptor antagonists are used to

Answer 3

strengthen neurotransmission and improve or maintain memory in those with dementia

Question 4

60-80% dementia is caused by

Answer 4

Alzheimer’s

Question 5

drugs used to treat alzheimers don’t –

Answer 5

cure the disease but slows the progression of dementia

Question 6

ex of cholinesterase inhibitors

Answer 6

donepezil (Aricept)
rivastigmine (Exelon)
galantamine (Razadyne)

Question 7

ex of NMDA receptor agonists

Answer 7

memantine (Namenda)

Question 8

Cholinesterase inhibitors act to increase the level of acetylcholine in the

Answer 8

CNS by inhibiting its breakdown and slowing neural destruction

Question 9

NMDA receptor antagonists work by decreasing the excitability of neurotransmission

Answer 9

caused by an excess of the amino acid glutamate in the CNS

Question 10

Cholinesterase inhibitors are used to:

Answer 10

treat early and moderate stages of dementia

related to AD

Question 11

Studies being done for treatment for —

Answer 11

severe cognitive decline as well as for other
dementias such as vascular or Parkinson’s
dementia

Question 12

adverse reactions of cholinesterase inhibitors

Answer 12

Anorexia, nausea, vomiting, diarrhea

Dizziness and headache