antihyperlipidemic

Question 1

Lipids (fat or fat-like substance) accumulate on the lining of blood vessels.

Answer 1

atherosclerosis

major contributing factor in heart disease

Question 2

2 lipids in our blood

Answer 2

• cholesterol

- triglycerides

Question 3

hyperlipidemia

Answer 3

increased lipids in blood

Question 4

how fats are transported in the blood

Answer 4

lipoprotein

Question 5

Low-density lipoprotein (LDL)

Answer 5

BAD

-resulting in atherosclerotic plaque formation

Question 6

High-density lipoprotein (HDL)

Answer 6

GOOD

-resulting in metabolism and excretion by the liver

Question 7

actions of Statins

Answer 7

1. inhibit manufacture of cholesterol

2. promote breakdown of cholesterol

Question 8

uses of Statins

Answer 8

1. Treatment of hyperlipidemia
   
   2. Primary prevention of coronary events
      (MI, TIA, Stroke)
   3. Secondary slow the progression of coronary
      atherosclerosis

Question 9

Statin adverse reactions CNS:

Answer 9

headache, dizziness, insomnia, memory and cognitive impairment

Question 10

Statin adverse reactions GI:

Answer 10

flatulence, abdominal pain, cramping, nausea, hyperglycemia in nondiabetic patients

Question 11

contraindications of Statins

Answer 11

1. Hypersensitivity

2. Serious liver disorders

Question 12

statin examples:

Answer 12

• atorvastatin (Lipitor)
• lovastatin (Mevacor)
• pravastatin (Pravachol)
• simvastatin (Zorcor)

Question 13

teaching for Statin

Answer 13

1. Taken in the evening at bedtime
   
   2. Do not take with grapefruit juice to prevent
      an enzyme reaction
   3. Can cause photosensitivity
   4. Notify primary health care provider if muscle
      pain, tenderness or weakness occurs