Exam 3 - Acid Base Balance Flashcards
what is an acid
substances that release hydrogen ions when dissolved in fluid and increase amount of free H
what is a base
binds free hydrogen ions in solution and lowers amount of free H
what is a buffer
tries to keep pH at normal levels - can bind hydrogen or release
what is the most common base in the human body
HCO3 (bicarbonate)
what is the most common acid in the human body
H2CO3 (carbonic acid)
what is the ratio of H2CO3 and HCO3 in the human body
1 H2CO3 : 20 HCO3
what does carbohydrate make as a waste product in normal metabolism
carbon dioxide
what does protein make as a waste product in normal metabolism
sulfuric acid
what does fat make as a waste product in normal metabolism
ketoacids
what are the two buffers? and where are they active?
phosphate (ICF) and bicarb (both ECF and ICF)
what are the two types of ECF protein buffers?
albumin and globulins
what is the ICF protein buffers?
hemoglobin
what are the kidneys defense for regulation
form ammonium, form acids or movement of bicarbonate
what happens in acidosis
excess amount of hydrogen ions (pH below 7.35)
what is actual acidosis
overproduction(release of H) or under elimination of acids (retention of H)
what is relative acidosis
amount of acids do not increase, amount of strength of bases decrease
where do the first manifestations occur for acidosis?
musculoskeletal, cardiac, respiratory, and central nervous system
what happens when there is a overproduction of hydrogen ions under elimination of hydrogen ions underproduction of bicarbonate ions and over elimination of bicarbonate ions?
metabolic acidosis
how does overproduction of hydrogen ions cause metabolic acidosis
excessive breakdown of fatty acids
anaerobic glucose breakdown (lactic acidosis)
excessive intake of acids
how is respiratory acidosis caused?
retention of co2