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AU14 Pharmacology > Exam 2; Schizophrenia and the Anti-Psychotic Drugs > Flashcards

Exam 2; Schizophrenia and the Anti-Psychotic Drugs Flashcards

1
Q

What are the 7 symptoms of schizophrenia

A 
delusions
hallucinations
disorders thinking
paranoia
inappropriate or bizarre behavior
violence
incontinence
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2
Q

What proportion of people in the hospital have schizophrenia

A

roughly 25% of all the beds at the hospital

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3
Q

What group of people is there a significant portion of those with schizophrenia

A

homeless people

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4
Q

What is the suicide rate of those with schizophrenia

A

greater than 10%

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5
Q

What are some supposed causes of schizophrenia

A

genetics
environmental (?)
there is evidence of excess activity of Da; link between schizophrenia and parkinson’s

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6
Q

This was the first anti-psychotic drug used; it suppressed the complex but not reflex behaviors

A

chlorpromazine

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7
Q

What are three symptoms of chlorpromazine

A

loss of initiative
disinterest in the environment
decrease in emotion

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8
Q

What is it that all the anti-psychotic drugs work in part by

A

blocking the dopamine receptors in the brain

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9
Q

What is the timing of anti-psychotic beginning to work

A

may take several weeks for the full effect of the drugs to take place

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10
Q

True or False

Patients can become addictive and tolerant to anti-psychotic drugs

A

False; it is non addictive and patients do not become tolerant

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11
Q

What is the mechanism behind typical (first gen.) anti-psychotic drugs

A

have a strong affinity for DA receptors and some affinity for histamine 1 receptors

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12
Q

These are two typical high potency anti-psychotics

A

haloperidol

pimozide

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13
Q

What class of drugs are the typical low potency anti-psychotic

A

“-zine’s”

triroidazine, etc.

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14
Q

What classes of drugs are the “atypical” anti-psychotic

A

“-done”
“-apine”
aripiprazole

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15
Q

What is the mechanism of atypical anti-psychotic drugs

A

strong affinity for dopamine, histamine-1, and SHT

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16
Q

What is the mechanism behind most anti-psychotic drugs

A

inhibit dopaminergic neurons

17
Q

anti-psychotics act on the cortical receptors causing these three symptoms

A

decreased delusions
decreased agitation
impaired intellectual function

18
Q

anti-psychotics act on the basal ganglia and cause what symptom

A

extrapyramidal symptoms

19
Q

anti-psychotic drugs can act on the hypothalamus and cause what to occur

A

inhibit the secretion of some hormones like GH or corticotropin releasing factor
lower body temperature

20
Q

anti-psychotic drugs can act on the chemoreceptor trigger zone to do what

A

decrease nausea

21
Q

What is the therapeutic index of anti-psychotics

A

very high; virtually impossible to kill you

22
Q

What are some major symptoms of anti-psychotics

A

Parkinson’s like effects; bradykinesia, dystonias, akasthisia, tardive diskinesthia

23
Q

How do anti-psychotics cause sedation

A

histamine1 blockade

24
Q

How do anti-psychotics cause postural hypotension

A

due to alpha-1 blockage

25
Q

What is the result of a hypersensitive reaction caused by anti-psychotics

A

rashes

26
Q

How do anti-psychotics alter the visual system

A

anticholinergic effects

chlorpromazine causes deposition of metabolism in the eye and leads to irreversible lens pigmentation

27
Q

How do anti-psychotics cause endocrine disturbances

A

increase in prolactin secretion

28
Q

This is much like malignant hyperthermia

A

neuroleptic malignant syndrome

29
Q

anti-psychotics can cause this; not feeling well when you take these agents

A

dysphoria

30
Q

What type of drug interaction can occur with anti-psychotics

A

interacts with CNS depressants

31
Q

What other symptoms are anti-psychotics used to treat

A 
bipolar
hiccups
nausea
Tourettes
OCD
stuttering
migraines

AU14 Pharmacology (29 decks)

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