Exam 2: Krebs Cycle Flashcards
Step 1: What happens?
Acetyl is attached to oxaloacetate, forming citrate (6 carbons)
Step 2: What happens?
Citrate re-arranges to isocitrate (6 carbons)
Step 3: What happens?
Isocitrate is oxidized to α-ketoglutarate. CO2 released, NADH formed (5 carbons)
Step 4: What happens?
α-ketoglutarate is oxidized…combines with CoA to form succinyl CoA…CO2 released NADH formed (4 carbons)
Step 5: What happens?
Succinyl CoA breaks down to CoA and succinate (4 carbons). Since this is exergonic, this drives formation of GTP from GDP and P. GTP can transfer phosphate to make ATP.
Step 6: What happens?
Succinate is oxidized into fumarate (4 carbons). FADH2 is formed.
Step 7: What happens?
Fumarate and water make malate (4 carbons)
Step 8: What happens?
Malate is oxidized into oxaloacetate (4 carbons). NADH is made.
Where does the Krebs cycle occur?
Matrix of mitochondria
In which steps are NADH produced from the reduction of NAD+ in TCAC?
Steps 3, 4, and 8
In which steps are CO2 formed in TCAC?
Steps 3 and 4
In which steps are FADH2 produced from the reduction of FAD?
Step 6
Final products from 1 glucose (2 TCAC)?
2 FADH2, 6 NADH, 4 CO2, 2 ATP
How many times does the cycle occur?
Twice
What is the acronym to rememeber the 8 compounds?
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