Exam 1: Dr. Kaplan Bridging Innate and Adaptive Immunity Flashcards
What does the adaptive response depend in for initiation?
Innate cells
What are the professional APCs?
Dendritic cell
Macrophage
B cell
What are the “inbetweeners”?
Cells that possess innate and lymphoid characteristics
List the inbetweeners?
γδ T cells
B-1 cells]
NKT cells
Innate lymphoid cells
What MHC is presented on all nucleated cells?
MHC class I
What MHC is presented on professional APCs?
MHC class I and II
What T cell does MHC class I recognize?
CD8
What T cell does MHC class II recognize?
CD4
What are innate-like lymphocytes?
Innate-like cells that impact adaptive immunity
What is different about innate-like lymphocytes when compared to lymphocytes?
Limited receptor rearrangement
No clonal expansion when stimulated
React promptly to infection
What are γδ T cells?
Innate-like T cell that expresses γδ TCR instead of the traditional αβ TCR
Where do γδ T cells reside?
Within epithelia, especially skin. Also in lymphoid tissue, genital tract
What are possible ligands for γδ T cells?
Proteins that get upregulated in response to infection or unusual nucleotides or phospholipids
What is different about what is recognized by γδ T cells when compared to αβ T cells?
The don’t usually recognize the antigen as an epitope presented by MHC, but rather recognize the antigens directly
What does γδ T cells recognizing antigen directly allow for?
Rapid response to a wide variety of molecules
What do γδ T cells secrete?
IFN-γ, TNF-α, antibacterial peptides, and granulysin
What do γδ T cells acquire during maturation?
The characteristics of professional APCs
What do γδ T cells express?
Different but limited receptor repertoires in different tissues
What does tissue repair function through in γδ T cells?
The secretion of fibroblast growth factor
What do B-1 B cells express?
CD5
Where do B-1 B cells reside?
Mainly in peritoneal and pleural cavities
What are the antibodies secreted by B-1 B cells like?
Low affinity, polyspecific, and made against bacterial polysaccharides and other carbohydrates