Essential Pharmacology Flashcards
What are the two basic functions of receptors?
Enable specificity
Evoke an appropriate response
Receptors are proteins that do what?
Recognise a specific compound or molecule
Agonists do what?
Mimic the normal effect of a receptor
Antagonists do what?
Block the normal action of a receptor
What is the name given to the strength of the chemical attraction between the drug and the receptor?
The affinity
The chemical messenger can enter a cell only if it is what?
Lipid soluble
Steroid hormones bind to what kind of receptors?
Intracellular
What does nitrous oxide bind to?
Soluble guanylyl cyclase
If a signalling membrane receptor cannot penetrate the cell, what is needed?
A plasma membrane receptor
An ionotropic receptor is when the receptor is also a what?
An ion channel
What does adenylyl cyclase produce?
cAMP
Adenylyl cyclase is an example of what?
A G-protein coupled receptor
Which types of receptors evoke slow IPSPs and slow EPSPs?
A g-protein recptor coupled directly to an ion channel
Give an example of a cell surface receptor?
Beta-blockers
If you increase the amount of drug given, what happens to the response?
It gets bigger
If you add more drug after all receptors have been bound, what happens?
There is no extra response, as receptors are saturated
Efficacy is what?
A determination of how good the drug is at activating the receptor
An antagonist will have what type of efficacy?
A very poor efficacy
What do agonists do?
Mimic the normal effect of a receptor
