Essential Pharmacology

Question 1

What are the two basic functions of receptors?

Answer 1

Enable specificity

Evoke an appropriate response

Question 2

Receptors are proteins that do what?

Answer 2

Recognise a specific compound or molecule

Question 3

Agonists do what?

Answer 3

Mimic the normal effect of a receptor

Question 4

Antagonists do what?

Answer 4

Block the normal action of a receptor

Question 5

What is the name given to the strength of the chemical attraction between the drug and the receptor?

Answer 5

The affinity

Question 6

The chemical messenger can enter a cell only if it is what?

Answer 6

Lipid soluble

Question 7

Steroid hormones bind to what kind of receptors?

Answer 7

Intracellular

Question 8

What does nitrous oxide bind to?

Answer 8

Soluble guanylyl cyclase

Question 9

If a signalling membrane receptor cannot penetrate the cell, what is needed?

Answer 9

A plasma membrane receptor

Question 10

An ionotropic receptor is when the receptor is also a what?

Answer 10

An ion channel

Question 11

What does adenylyl cyclase produce?

Answer 11

cAMP

Question 12

Adenylyl cyclase is an example of what?

Answer 12

A G-protein coupled receptor

Question 13

Which types of receptors evoke slow IPSPs and slow EPSPs?

Answer 13

A g-protein recptor coupled directly to an ion channel

Question 14

Give an example of a cell surface receptor?

Answer 14

Beta-blockers

Question 15

If you increase the amount of drug given, what happens to the response?

Answer 15

It gets bigger

Question 16

If you add more drug after all receptors have been bound, what happens?

Answer 16

There is no extra response, as receptors are saturated

Question 17

Efficacy is what?

Answer 17

A determination of how good the drug is at activating the receptor

Question 18

An antagonist will have what type of efficacy?

Answer 18

A very poor efficacy

Question 19

What do agonists do?

Answer 19

Mimic the normal effect of a receptor