Bones Flashcards

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1
Q

What are the four main functions of bone in the body?

A

Mechanical
Protective
Metabolic
Haemtopoiesis

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2
Q

What are the two types of ossification?

A

Endochondral

Intramembranous

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3
Q

In endochrondal ossification, bones form as what?

A

Cartilage

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4
Q

In intramembranous ossification, bones form as what?

A

Fibrous Plate

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5
Q

What are the 3 main components of bone?

A

Water
Protein
Minerals

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6
Q

What are the epiphyses of long bone composed of?

A

Trabecular (spongey) bone

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7
Q

What are the diaphyses of long bone composed of?

A

Cortical bone

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8
Q

What do osteoclasts do?

A

Resorb bone

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9
Q

What do osteoblasts do?

A

Lay down more bone

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10
Q

How do bones keep themselves at peak strength?

A

They are constantly monitored and remodelled

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11
Q

Where are osteocytes derived from?

A

The differentiation of osteoblasts

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12
Q

What do osteocytes act as?

A

Sensors of mechanical pressure and damage

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13
Q

Which type of bones use endochondral ossification?

A

Long bones

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14
Q

At what age would a growth plate be expected to fuse in a female?

A

18

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15
Q

Which type of bones undergo intramembranous ossification?

A

Flat bones

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16
Q

What does collagen type 1 provide in the composition of bone?

A

The toughness of the bone

17
Q

What shape is a collagen molecule?

A

Triple helix

18
Q

What do stromal cells produce?

A

Growth factors for haemopoiesis

19
Q

Osteoclasts derive from what?

A

Haematopoietic precursor cell

20
Q

Osteoblasts derive from what?

A

Mesenchymal precursor cell

21
Q

What are osteoblasts extremely rich in?

A

Endoplasmic reticulum

Golgi Apparatus

22
Q

What are biphosphonates inhibitors of?

A

Bone resorption