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esophageal disorders Flashcards

1
Q

esophageal symptoms

A

Dysphagia, odynophagia (painful swallowing), GERD/”heartburn” symptoms almost always indicate a primary esophageal disorder

-Esophageal dysphagia can be caused by mechanical lesions or by motility disorders
Dysphagia can be worse with solids vs. liquids or issues can be the same given solid or liquid boluses
-Dysphagia can be due to the oropharyngeal phase of swallowing or the esophageal phase of swallowing

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2
Q

Causes of oropharyngeal dysphagia and esophageal dysphageal

A

-Oropharyngeal dysphagia is caused by a variety of mechanical and neuromuscular conditions:
Drooling, food falling from the mouth, dry mouth, or inability to initiate swallow are hallmarks
-Esophageal dysphagia can be caused by mechanical lesions or by motility disorders
Dysphagia can be worse with solids vs. liquids or issues can be the same given solid or liquid boluses

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3
Q

Neurologic disorders that can cause oropharyngeal dysphagia

A

Brainstem mass, stroke
ALS, MS, GBS
Parkinson’s disease, Huntington disease
Tardive dyskinesia

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4
Q

Autoimmune issues that can cause oropharyngeal dysphagia

A

Myopathies, polymyositis

Sjogren’s syndrome, sicca

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5
Q

metabolic disorders that can cause oropharyngeal dysphagia

A

Thyrotoxicosis, amyloidosis

Cushing disease, Wilson disease

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6
Q

IDs that can cause oropharyngeal dysphagia

A

Polio, diphtheria, botulism, Lyme disease, syphilis, candida, HSV, CMV

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7
Q

Structural disorders that can cause oropharyngeal dysphagia

A 
Zenker diverticulum
Cervical osteophytes, esophageal webs
Oropharyngeal tumors
Radiation changes
Pill ulcer
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8
Q

motility disorders that can cause oropharyngeal dysphagia

A

Upper esophageal sphincter dysfunction

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9
Q

Causes of Esophageal Dysphagia: Mechanical obstruction: Solids worse than liquids

A

Schatzki ring – intermittent dysphagia, not progressive
Peptic stricture – chronic heartburn, progressively worse
Esophageal cancer – progressively worse, usually age older than 50yo, smoker/drinker
Eosinophilic esophagitis – young adults, strictures, papules

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10
Q

Causes of Esophageal Dysphagia: Motility disorders:  Solid and liquid foods equally

A

Achalasia – progressive dysphagia
Diffuse esophageal spasm (DES) – intermittent, presents with chest pain
Scleroderma (AI) – chronic heartburn, substernal discomfort

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11
Q

slide 6, dx?

A

Schatzki ring on barium swallow, ring of esophagus gets pinched down, may regurgitate food bolus, then may swallow just fine

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12
Q

slide 7??

A

“bird’s beak appearance”: esophageal achalasia

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13
Q

case: hx RA, w. painful swallowing worse over 2 wks, some substernal burning
questions?

A

worse with laying down
has had Raynaud’s in past
ask what on for RA (naproxen, steroids can affect esophagus)
dx: odynophagia

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14
Q

odynophagia is ??

Often due to infectious etiologies such as ??

This should be in the differential for ??

A

Odynophagia is sharp, substernal pain on swallowing
-esophageal candida, herpes, or CMV
-immunocompromised patients, HIV patients, etc.
tx empirically

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15
Q

dx studies : Upper Endoscopy (EGD)

A

Study of choice for evaluating persistent GERD, dysphagia, odynophagia, and structural abnormalities
-Biopsy, cultures, and intervention can be performed if warranted

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16
Q

Barium esophagography

A

Dysphagia patients often evaluated via barium swallow first before EGD is performed
If a high suspicion exists for a mechanical lesion, EGD often is done first
(intervention can be done at same time)

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17
Q

Esophageal manometry

A

Determines the etiology of dysphagia in patients where there is no obvious mechanical obstruction
Done pre-op as well prior to anti-reflux surgeries (Nissen fundoplication)

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18
Q

Esophageal pH recording

A

Provides information regarding esophageal reflux

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19
Q

case 2: smokes 1 PPD, 2 beers/night, chronic cough

A

GERD

20
Q

GERD ??

A

a condition that develops when the reflux of stomach contents causes substernal burning, chronic cough, foul taste, etc.
Affects 20% of adults

Impaired lower esophageal sphincter
This is essentially a barrier to reflux when functioning properly
Normal pressure is 10-30mmHg
Patients with severe erosive GERD often have a sphincter tone of less than 10mmHg
-impaired tone in pregnancy!

21
Q

GERD: irritant effects ??

what is associated with more severe esophagitis??

A

Mucosal damage, gastric acid often with a pH less than 4.0

Hiatal hernias, esp. associated w. Barrett esophagus

22
Q

Symptoms of GERD

A

Typical symptom is heartburn
Usually 30-60min after eating and while reclining
Relief with antacids, patients will often report taking daily

23
Q

Diagnosis of GERD

A

Occasionally diagnosed with a trial of PPIs
-Essentially a clinical diagnosis and empiric therapy
-The “purple pill” 14 day challenge
EGD or Esophageal pH testing can be considered as well
-Biopsy can help delineate the extend of mucosal damage

24
Q

GERD complications: Barrett Esophagus

A

Condition where the squamous epithelium of the esophagus is replaced by columnar epithelium containing goblet and columnar cells
This is essentially a metaplastic process and can lead to malignancy
Present in up to 10% of those with severe, chronic reflux induced injury
Hallmark is the presence of orange, gastric type epithelium that extends from the stomach into the esophagus in a circumferential manner

25
Q

most serious GERD/Barrett Esophagus complication

monitor how??

A

Most serious potential complication is esophageal CA

EGD every 3-5 years recommended to look for changes

26
Q

more GERD complications: peptic stricture

A

Stricture formation occurs in about 5% of those with chronic esophagitis
Usually presents with gradual solid food dysphagia over months to years
Usually located at the GE junction
-Patients usually require, and benefit from, dilation with gradual catheters inserted over guide wires or balloon procedures (be careful not to perf)
-A luminal diameter of ~15mm is needed to relieve dysphagia
-Long term PPI use is required to try and reduce the chance of relapse (but almost always relapse)

27
Q

GERD tx: Mild Intermittent Symptoms

A

Lifestyle modifications
Avoid bothersome foods (citrus, tomatoes, coffee, spicy foods, chocolate, fatty foods, peppermint, alcohol)
Antacids are the mainstay of therapy for rapid relief
OTC oral H2-receptor blockers – cimetidine, ranitidine, famotidine

28
Q

GERD tx: Troublesome Symptoms

A

PPIs become the mainstay of therapy
Take 30min before breakfast for 4-8 weeks
Some patients may require BID therapy

29
Q

GERD tx: Long-term Therapy

A

Many patients experience relapse and begin continuous PPI therapy

30
Q

GERD sx tx

A

Nissen fundoplication has an 85% success rate in controlling symptoms and ultimately healing esophagitis
SEs however, including dysphagia, bloating, flatulence, dyspepsia and diarrhea happen in over 30% of patients
Not recommended in patient currently well controlled with PPIs (only refractory cases)

-grab on fundus of stomach and wrap around LES creating more pressure, limits reflux but changes anatomy (slide 21)

31
Q

Infectious Esophagitis

A
  • Most common cause of odynophagia and dysphagia*
  • Often present with substernal chest pain or discomfort
  • Oral thrush is a poor indicator, however should be assessed for possible clues (but may imply yeast in oropharynx)
  • Also look for oral ulcers or consideration for CMV infection in other sites (retina, colon) esp. in HIV pts
  • Serologic testing: HSV, CMV (“CMV colitis”)
32
Q

case 3: tick bite, erythema migrans (Lyme disease) -typically where bite occurred, may have satellite lesions
man being tx, presents halfway w. c/o sev. retrosternal CP, dysphages after meds, feels like he is swallowing over a lump

dx? what is the tx he is on?

A

pill ulcer: Pill induced esophagitis

doxycycline (for Lyme): ulcer inducing

get EGD, may find pill, ulcer may feel like a lump

33
Q

Pill-Induced Esophagitis

A

Caused by numerous medications, classically NSAIDs, potassium, iron, Vitamin C, and antibiotics (especially tetracycline and doxycline

  • More likely to occur if pills are swallowed without water or with minimal water
  • May occur suddenly and persist for days
  • Chronic injury can result in severe esophagitis, hemorrhage, or even perforation
34
Q

Pill-Induced Esophagitis: other caustic injuries caused by toxic ingestions

A

Suicide attempts or accidental consumption by children
Burning, pain, gagging, dysphagia, drooling
-dishwater pods look like gummies

35
Q

Mallory-Weiss Syndrome

A

A non-penetrating mucosal tear at the G-E junction that generally results from increased transabdominal pressure
What patient population might you classically see this in? alcoholics, bulimics
-Sometimes can present with hematemesis or melena too (typ. blood tinged vomit)

36
Q

Mallory-Weiss Syndrome tx

A

Treated with injection of epinephrine or cautery if there is active bleeding that does not spontaneously resolve

37
Q

Zenker Diverticulum

A

protrusion of pharyngeal mucosa at the pharyngoesophageal junction

  • Symptoms include dysphagia, halitosis (bad breath), and regurgitation of undigested food
  • Often occurs in the elderly and complications can include aspiration pneumonia and lung abscesses as well
  • Curative treatment is a surgical diverticulectomy
38
Q

case 4: known chronic etOH dependence, ER w. substernal pain, hematemesis, waning mental status, hypotensive, projectile vomiting

A

Esophageal Varices

39
Q

Esophageal Varices

A

Dilated submucosal veins that develop in patients with serious portal hypertension

  • Severe upper GIB may occur
  • Bleeding varices can present with severe hematemesis and shock
  • 50% of all cirrhotics have esophageal varices, and 30% of them will experience bleeding at some point
  • Tx can be multifactorial depending on the severity of the varices and the severity of the underlying disease
40
Q

Esophageal Varices tx options

A
  • Antibiotic prophylaxis: High risk of SBP (spont. bac. peritonitis) or pneumonia
  • Vasoactive drugs: Somatostatin and octreotide – reduce splanchnic and hepatic blood flow
  • Vitamin K
  • Lactulose for encephalopathy which can complicate an acute variceal bleeding episode
  • Emergent endoscopy: Banding or balloon tamponade
41
Q

Portal Decompressive Procedures : TIPS – Transvenous Intrahepatic Portosystemic Shunt

A

Over a wire that is passed through the jugular vein, a mesh stent is passed through the liver parenchyma crating a shunt from the portal vein to the hepatic vein
Can control acute hemorrhage 90% of the time.
Also a strategy for the prevention of re-bleeding in those with severe bleeds
slide 29 pic

42
Q

Portal Decompressive Procedures: Portosystemic shunt

A

When TIPS procedure is unavailable, shunt surgery can be performed to create similar shunting from the portal vein to the hepatic vein
40-60% mortality when done in emergency situations

43
Q

Esophageal Achalasia

A

Gradual, progressive dysphagia for solids and liquids

  • Loss of peristalsis in the distal 2/3rds (smooth muscle) of the esophagus
  • 50% experience substernal chest pain
  • Regurgitation of undigested food
  • Patients may lift their chins or throw their shoulders back to get food to move through
  • Barium esophagram with “bird’s beak” appearance to the distal esophagus (also looks like esophageal ca, but w. less systemic symps)
  • Diagnosis confirmed with esophageal manometry
44
Q

Esophageal Achalasia tx: Botulinum toxin injection

A

Results in marked reduction in LES pressure with initial improvement in symptoms in the majority of patients
Relapse reoccurs almost universally by 2 years

45
Q

Esophageal Achalasia tx: Pneumatic dilation

A

Less effective in younger patients, but the majority get a long lasting response
Relapse common around the 10 year mark

46
Q

Esophageal Achalasia tx: Surgical myotomy

A

Excellent improvement in 90% of patients however GERD is a common side effect of the procedure
Fundoplication often performed at the same time

CSI (75 decks)

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