Epithelium Flashcards

1
Q

Epithelial tissue

A

Covers the body surface/ lines body cavities
Avascular
Derive nutrients via diffusion from blood vessels in the underlying CT

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2
Q

What is the function of epithelial tissue cells in the intestine?

A

Absorption

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3
Q

What is the function of epithelial tissue cells in glands?

A

Secretion

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4
Q

What is the function of epithelial tissue cells in the skin?

A

Protection

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5
Q

What is the function of epithelial tissue cells in the neuroepithelium?

A

Sensory

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6
Q

What is the function of epithelial tissue cells in the myoepithelial?

A

Contractility

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7
Q

Basement Membrane

A

Separates the epithelial tissue from CT
Basal lamina, collagen, glycoproteins and heparin sulphate form the BM
PAS-positive and seen with LM

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8
Q

How can you classify epithelium?

A

Simple, stratified, and pseudostratified

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9
Q

Simple Epithelium

A

All cells life on the basal lamina
3 types: squamous, cuboidal and columnar

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10
Q

Stratified Epithelium

A

Has more than one layer and cell on the bottom layer lie on the basal lamina
4 types of stratified: squamous cuboidal, columnar and transitional

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11
Q

Pseudostratified

A

All cells lie on the basal lamina but appear stratified because their nuclei are in different locations

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12
Q

What can change the epithelium from one type to another?

A

A continuous abrasion or irritation.
Ex: stratified squamous non-keratinized to keratinized in the esophagus when milk diet is replaced by roughage in young animals
Or
Pathological change
Ex: pseudo-stratified columnar to stratified squamous in respiratory tract because of continuous smoke inhalation (metaplasia)

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13
Q

What is the most prevalent epithelium?

A

stratified squamous (keratinized or nonkeratinized)

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14
Q

How often is epithelia replaced?

A

Continuously replaced but the rate of replacement is variable

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15
Q

Microvilli

A

1 micrometer high and 80 nm wide
Function: increase the surface area of absorptive cells (intestine and kidney) by 15-40 times
ABSORPTION

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16
Q

Brush border

A

Microvilli grouped together, individual microvilli cannot be seen under the LM
AKA striated border

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17
Q

Stereocilia

A

10- 20 um
Long immotile microvilli
Present in the epididymus
Function: absorb testicular fluid

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18
Q

Cilia

A

Hair like processes 7-10um high, 0.2 um diameter
Consists of 2 central microtubules and 9 peripheral microtubule pairs
Function: moving cells and fluid past the cells

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19
Q

What does each peripheral microtubule pair have?

A

2 little dynein arms and a motor protein that used energy from ATP to hook up the next pair of microtubules

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20
Q

Kartagener Syndrome (Immotile Cilia Syndrome)

A

When a patient genetically lacks dynein arms
They’re infertile
More prone to respiratory syndrome

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21
Q

Flagellum

A

Lagrer than cilium
Present in the sperm tail

22
Q

Intercellular Junctions

A

Provide adhesions between cells and restrict movement of materials in and out of the lamina

23
Q

Junctional Complex (terminal bar)

A

Membrane-associated structures that function in cell-to cell attachment of simple epithelia
3 components: Zonula occludens, Zonula adherens, and macula adherens

24
Q

Zoluna Occudens (ZO)

A

Surrounds the entire apical circumference of adjacent cells
Function: prevents substances from moving into the intercellular space from the lumen

25
Q

Zonula adherens (ZA)

A

Intermediate Junctions
Surrounds the entire circumference of adjacent cells
Variation: fascia adherens
Function: binding of adjacent cells, linking cells to form a network

26
Q

Macula adherens (MA)

A

Desmosome
Function: Provides firm binding between cells
Well developed in the stratifed epithelia (skin)

27
Q

Hemidesmosome

A

Variation of a desmosome
Binds the epithelium with the underlying CT

28
Q

Gap Junction

A

Couple adjacent cells metabolically and electrically
Made of 6 connexins
Communication between cells of signaling molecules (ions, hormones, AMP and GMP)- coordination

29
Q

Exocrine Glands

A

Secrete via a duct on the epithelium of its origin
EX: salivary glands
Modes of secretion: Holocrine, merocrine and aponcrine

30
Q

Endocrine glands

A

Not connected to epithilial surface, no duct and secrete into the bloodstream
EX: paracrine and autocrine glands
Location: thyroid glands

31
Q

where do paracrine and autocrine glands secrete?

A

Into the local extracellular space
P: acts on nearby cells (not the ones that produce them)
A: acts on the same cell that secretes it

32
Q

Mucus secretion

A

Viscous material that protects/ lubricates cell surfaces

33
Q

Serous Secretion

A

Watery secretion that is often rich in enzymes

34
Q

Mixed Secretion

A

Contains both mucus and serous

35
Q

Merocrine cells

A

Release only secretory granules by exocytosis with no loss of cytoplasm
99% of secretion

36
Q

Apocrine cells

A

Release secretory product with some apical cytoplasm
Sweat glands in domestic animals

37
Q

Holocrine Cells

A

Release secretory product with all cytoplasmic contents (these cells die)

38
Q

What is the difference between Basil Lamina and the Basement Membrane?

A

BL is made of type 4 collagen and glycoproteins and is seen on the EM level
BM is made of basal lamina and type 1 collagen fibers and can be seen on the LM level

39
Q

Simple gland

A

Duct does not brach

40
Q

Compound gland

A

Duct branches

41
Q

What controls the secretion of hormones by the endocrine glands?

A

Metabolic factors, secretion of other hormones and the nervous system

42
Q

Ciliogenesis

A

Centrioles duplicate, each centriole moves near the apical cell membrane (now called basal body) and gives rise one cilium.

43
Q

Simple Squamous

A

C: one layer, flat, spaced out
L: blood vessels (endothelium), body cavities (mesothelium)
F: Diffusion

44
Q

Simple Cuboidal

A

C: one layer, tightly connected, cubed/ rounded
L: kidney, salivary glands, pancreas
F: Absorption
SC: microvilli

45
Q

Simple Columnar

A

L: small intestine, stomach, respiratory tract
F: secretion and absorption
C: Tall, central nuclei

46
Q

Simple Columnar Ciliated

A

L: uterus
F: ovum transport, propels particles over epithelium surface
C: Columnar, tall
SC: cilia

47
Q

Pseudostratified Columnar (ciliated)

A

C: looks like more than one layer, nuclei at different places
L: bronchus, epididymus
F: cilia propels mucus and particles to the pharynx
SC: cilia, goblet cells

48
Q

Stratified Squamous

A

C: multilayer, cuboidal based, polygonal middle, flat squamous superficial
L: oral cavity, skin, pharynx, vagina
F: Withstand abrasion and water proof
SC: keratinized or non keratinized

49
Q

What has keratinized stratified epithelium?

A

skin

50
Q

Stratified Cuboidal

A

C: multilayer, cuboidal/rounded,
L: exocrine gland ducts
F:Provides robust lining

51
Q

Stratified Transitional

A

C: 4-5 layers thick
L: bladder
F: stretch and withstand urine toxicity

52
Q

Dynein Arms

A

Motor proteins that uses energy from ATP to hook up to the next pair of micro tubules