Enveloped RNA Viruses

Question 1

Single-stranded – sense RNA viruses with segmented genome ?

Answer 1

Orthomyxoviruses (influenzaviruses)

Question 2

They have non-segmented single-stranded RNA ?

Answer 2

Paramyxoviruses

Question 3

What is the Structure of Orthomyxoviruses (influenzaviruses) ?

Answer 3

1- Single-stranded – sense RNA viruses with  segmented genome
2- helical symmetry 
3- virus envelope (glycoprotein) : 
hemagglutinin (HA)
neuraminidase (NA)

Question 4

What is the influenza that cause pandemics ?

Answer 4

influenza A

Question 5

has wide host range & antigenically highly variable → antigenic shift→ pandemics ?

Answer 5

influenza A

Question 6

based on core antigen is Subtypes according to ?

Answer 6

HA (16)& NA (9)

Question 7

bind to sialic acid to enter the cell ?

Answer 7

hemagglutinin (HA)

Question 8

penetrate the mucus &make the envelope ?

Answer 8

neuraminidase (NA)

Question 9

antigenically highly variable ?

Answer 9

influenza A

Question 10

human only pathogen ?

Answer 10

influenza B

Question 11

antigenically stable ?

Answer 11

influenza C

Question 12

human only pathogen, has minor antigenic changes→ antigenic drift ?

Answer 12

influenza B

Question 13

antigenically stable, causes mild illness in immunocompetent individuals ?

Answer 13

influenza C

Question 14

Antigenic shift: a major antigenic change due to ?

Answer 14

Genetic reassortment

Question 15

Minor antigenic variation due to point mutation affects HA & NA ?

Answer 15

Antigenic drift

Question 16

Orthomyxoviruses (influenzaviruses) is Transmitted by ?

Answer 16

droplet

Question 17

What is the vaccine of Orthomyxoviruses (influenzaviruses) ?

Answer 17

Killed vaccine

Question 18

Killed vaccine is very safe for all people including ?

Answer 18

pregnant

Question 19

What is the Disease of Orthomyxoviruses (influenzaviruses) ?

Answer 19

1- Influenza

2- Avian influenza by H5N1 virus

Question 20

What is the Complications of Orthomyxoviruses (influenzaviruses) ?

Answer 20

1- Pneumonia

2- Reye’s Syndrome

Question 21

Reye’s Syndrome contains?

Answer 21

encephalopathy + liver degeneration

Question 22

In the Avian influenza by H5N1 virus , the virus has scant receptor in ?

Answer 22

alveoli

Question 23

transmitted by close contact with diseased bird, rare human to human transmission ?

Answer 23

Avian influenza by H5N1 virus

Question 24

What is the structure of Paramyxoviruses ?

Answer 24

1- They have non-segmented single-stranded RNA
2- have helical symmetry
3- fusion (F) protein
4- They are antigenically stable

Question 25

What is the most important cause of bronchiolitis and pneumonia in infants ?

Answer 25

Respiratory syncytial virus (RSV)

Question 26

Respiratory syncytial virus (RSV) is Severe cases in children is treated by ?

Answer 26

Ribavirin aerosol

Question 27

Respiratory syncytial virus (RSV) is ?

Answer 27

the most important cause of bronchiolitis and pneumonia in infants

Question 28

What is the common cause of respiratory diseases in infants and young adults ?

Answer 28

Human parainfluenza viruses 1,2,3,4

Question 29

HPIV-1 & HPIV-2 →cause ?

Answer 29

croup and barking cough

Question 30

HPIV-3 →cause ?

Answer 30

common cold +fever, pneumonia.

Question 31

HPIVs are second to RSV as a ?

Answer 31

common cause of respiratory diseases in infants and young adults.

Question 32

Mumps virus is spreads to ?

Answer 32

meninges and glands

Question 33

What is the Disease of Mumps virus ?

Answer 33

epidemic parotitis and aseptic meningitis

Question 34

What is the complication of Mumps virus ?

Answer 34

1-Pancreatitis 2- Oophoritis 3- Orchitis 4- sterility.

Question 35

What is the vaccine of Mumps virus ?

Answer 35

Mumps Vaccine within MMR(measles, mumps, rubella), type: live-attenuated

Question 36

What is the Mode of Transmission of Measles virus ?

Answer 36

air-borne =very contagious

Question 37

what is the Complications of Measles virus ?

Answer 37

1- pneumonia | 2- Sub acute sclerosing panencephalitis (SSPE)

Question 38

What is the disease of Rubella virus ?

Answer 38

1- Postnatal Rubella (German Measles) | 2- Congenital rubella syndrome→ caused by Togavirus

Question 39

What is the vaccine of Rubella virus ?

Answer 39

MMR vaccine

Question 40

MMR vaccine contains three live, attenuated viruses ?

Answer 40

1- Mumps 2- Measles 3- Rubella

Question 41

What is the Feature of Corona viruses ?

Answer 41

enveloped, RNA viruses with club-shaped surface spikes ( corona)

Question 42

The Severe acute respiratory syndrome of Corona viruses is by ?

Answer 42

SARS-CoV

Question 43

In the Corona viruses the Middle East Respiratory Syndrome (MERS) is by ?

Answer 43

MERS-CoV

Question 44

What is the is the most important cause of bronchiolitis and pneumonia in infants and children <2 years ?

Answer 44

Respiratory syncytial virus (RSV)

Question 45

In the Mumps virus the , the virus spreads to multiple tissues, including the ?

Answer 45

meninges and glands

Question 46

In the Mumps virus the Inflammation in infected tissues leads to characteristic symptoms of ?

Answer 46

parotitis and aseptic meningitis

Question 47

What is the complication of Mumps virus ?

Answer 47

1- Severe aseptic meningitis in adults. 2- Orchitis in adult males that may lead to sterility. 3- Pancreatitis 4- Oophoritis & thyroiditis.

Question 48

In the Mumps virus the ELISA is used for ?

Answer 48

detection of IgM

Question 49

Measles virus can also be spread by the ?

Answer 49

airborne route.

Question 50

koplik's spots" in ?

Answer 50

Measles virus

Question 51

maculopapular rash appears all over the body in the ?

Answer 51

Measles virus

Question 52

ELISA is used for detection of IgM in the ?

Answer 52

1- Mumps virus | 2- Measles virus

Question 53

In the measles virus the Live attenuated vaccine is given by injection to children at the age of ?

Answer 53

15 months