Endocrinopathies in Pregnancy

Question 1

what hormones does the first trimester stimulate ?

Answer 1

stimulates Progesterone estradiol, and free estriol with human placental lactogen

Question 2

metabolic changes you can experience in pregnancy

Answer 2

Increased erythropoetin, cortisol, noradrenaline
High cardiac output
Plasma volume expansion
High cholesterol and triglycerides
Pro thrombotic and inflammatory state
Insulin resistance

Question 3

gestational syndromes you can experience in pregnancy

Answer 3

Pre-Eclampsia
Gestational Diabetes
Obstetric cholestasis
Gestational Thyrotoxicosis
Transient Diabetes Insipidus
Lipid disorders
Postnatal depression
Postpartum thyroiditis
Postnatal autoimmune disease
Paternal Disease

Question 4

when does Fetal thyroid follicles and thyroxine synthesis occur?

Answer 4

week 10

Question 5

what occurs at 10 weeks in terms of thyroid gland development?

Answer 5

Fetal thyroid follicles and thyroxine synthesis

Question 6

what happens at week 15-20- thyroid gland development?

Answer 6

axis

Question 7

what does Maternal T4 0-12 weeks regulate?

Answer 7

Maternal T4 0-12 weeks regulates neurogenesis, migration and differentiation then fetal T4

Question 8

describe the structure of glycoprotein hormones?

Answer 8

2 subunits
a common alpha
a distinct beta subunit
TSH
LH
FSH
hCG

Question 9

Signs and symptoms of hypothyroidism in pregnancy?

Answer 9

Weight gain, cold intolerance, poor concentration, poor sleep pattern, dry skin, constipation, tiredness,

Question 10

how does hypothyroidism affect the pregnancy?

Answer 10

Inadequate treatment
Gestational hypertension
Placental abruption
Post partum haemorrhage
If untreated
Low birth weight
Preterm delivery
Neonatal goitre
Neonatal respiratory distress

Question 11

what is the targeted screening for hypothyroidism in pregnancy?

Answer 11

Age >30
BMI >40
Miscarriage preterm labour
Personal or family history
Goitre
Anti TPO
Type 1 DM
Head and neck irradiation
Amiodarone, Lithium or contrast use