drug development

Question 1

what are the current models of drug development?

Answer 1

Lead compound identification
Pre-clinical research
Filing for regulatory status
Clinical trials on humans
Marketing the drug

Question 2

define druggability

Answer 2

the ability of a protein target to bind small molecules with high affinity (sometimes called ligandability).

Question 3

what recombinant proteins are used in clinical use?

Answer 3

Insulin
Erythropoietin
Growth hormone
Interleukin 2
Gamma interferom
interleukin 1 receptor

Question 4

what is gene therapy

Answer 4

Gene therapy consists of a recombinant nucleic acid used in or administered to a human being with a view to regulating, replacing, adding or deleting a genetic

Question 5

what does the effect of gene therapy relate to?

Answer 5

Its effect relates directly to the recombinant nucleic acid sequence it contains or to the product of genetic expression of this sequence

Question 6

what is rational drug design

Answer 6

The process of finding new medications based on the knowledge of a biological target

Question 7

what does rational drug design involve

Answer 7

Involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it

Question 8

what does rational drug design rely on?

Answer 8

Relies on the knowledge of the 3D structure of the biomolecular target – structure-based drug design

Question 9

what can drugs be developed from?

Answer 9

Medicines from plants
Digitalis plant used for dropsy (heart failure) – digoxin
Inorganic elements
Organic molecules
Chloroform
Phenol
Bacteria/fungi/moulds
Stereoisomers (have the same molecule formula and sequence of bonded atoms, but differ in the 3D orientations of their atoms in space)
Immunotherapy antibodies
Vaccinations for hep B, influenza, tetanus, mumps
Medicines from animals
Gene therapy