Endocrinology Flashcards
What is the neuro control center for reproductive hormones? What are the components of this center?
Hypothalamus
Consists of ..
Proventricular nucleus PVN
Surge center
Tonic center
T/F: the surge center of the hypothalamus is only present in females, not males
True
Both males and females have a tonic center
Hypothalamic nuclei front he surge and tonic center terminate in the _______________
Hypothalamic-hypophyseal portal system (H-HPS)
Characteristics of reproductive hormones?
Act in small quantities
Short half life
Bind specific receptors
Cause release of other hormones Can stimulate the gonads Can cause sexual promotion Can help maintain pregnancy Leuteolysis
Where is GnRH released from?
Hypothalamic nuclei
What hormones are released from the anterior pituitary?
FSH
LH
prolactin
What hormones are released from the posterior pituitary?
Oxytocin
T/F: FSH and LH are decapeptide hormones
False
GnRH is a decapeptide
FSH, LH, and inhibin are glycoproteins (large molecule requiring a receptor)
Progesterone, testosterone and estradiol are all produced from what common molecule ?
Cholesterol
(Steroid/protein) hormones travel freely through plasma membrane into cytoplasm and bind directly to specific nuclear receptors
Steroid
Results in new protein synthesis
What is the target tissue of LH in the female vs the male?
Female — ovary theca interval and luteal cells
Male —testis leydig cells
What is the target tissue of FSH in the female vs the male?
Female — ovary (granulosa cells)
Male — Sertoli cells
What factors determine the strength of hormones?
Pattern and duration of secretion
Half life
Receptor density
Receptor-hormone affinity
Episodic hormone secretion is associated with hormones under ________ control
Nervous
In what type of hormone secretion pattern does the hormone stay low, but may fluctuate at very low levels
Basal
Where are steroid hormones metabolized and excreted?
Met in liver and excreted in urine and feces
Where are protein hormones metabolized and excreted?
Met — Liver and kidney
Ex in urine