Endocrine: Pituitary Gland, Thyroid Gland Flashcards

1
Q

“AR form of short stature due to extreme resistance to GH because abnormalities in GH receptor”

A

Laron Syndrome

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2
Q

“hypogonadic hypogonadism due to GnRH deficiency and anosmia, cleft lip/ palate)

A

Kallmann Syndrome (isolated gonadotropin deficiency)

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3
Q

“hereditary predisposition to pituitary adeonoma, parathyroid hyperplasia or adenoma, pancreatic islet cell adenoma”

A

MEN I mutation

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4
Q

What will Parafollicular C cells stain (+) for?

A

chromogranin (+)

synaptophysin (+)

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5
Q

“complete absence of thyroid tissue, not uncovered until several weeks after birth”

A

thyroid agenesis

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6
Q

“thyroid that is outside the normal area”

A

ectopic thryoid

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7
Q

“thyroid tissue located lateral to the jugular veins or in lymph nodes and soft tissue adjacent to the thyroid glands”

A

lateral aberrant thyroid

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8
Q

Is a male or a female more likely to have a lingual thyroid?

A

female (found with difficulty swallowing, speaking or breathing)

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9
Q

“nests of thyroid tissue found anywhere along the path of its descent into the lower neck”

A

heterotropic thyroid tissue

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10
Q

“failed complete involution and cystic fluid filled remnant along the thyroglossal duct”

A

thyroglassal duct cyst

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11
Q

What are the two different histologic forms of nontoxic goiter?

A

Diffuse= early in disease

multinodular= late in disease/ chronic

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12
Q

What is myxedema?

A

boggy faces, puffy eyelids, edema of the hands and feet and enlarged tongue

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13
Q

What is thyroiditis?

A

inflammatory disorder of the thyroid

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14
Q

Histology seen in hashimotos?

A

Lymphocyte and plasma cell infiltrate

Hyrthle/ Askanazy cells–> follicular epithelial cells with oxyphilic metaplasia, filled with mitochondria and showing nuclear atypia

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15
Q

Histologic pattern of embryonal thyroid adenoma?

A

trabecular pattern with poorly formed follicles containing little of no colloid

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16
Q

Histologic pattern of fetal thyroid adenoma?

A

similar to embryonal adenoma but cells are arranged in microfollicles contaning little colloid

17
Q

Histologic pattern of simple thyroid adenoma?

A

mature follicles with a normal amount of colloid

18
Q

Histologic pattern of colloid thyroid adenoma?

A

simple adenoma but follicles are larger with more colloid

19
Q

Histologic pattern of Hurthle (oncocytic) carcinoma?

A

Solid tumor with oxyphil cells, small follicles and scant colloid, become infarcted after needle aspiration biopsy

20
Q

Most common thyroid cancer?

A

papillary thyroid cancer

21
Q

What is diagnostic of papillary thyroid cancer?

A

Calcospherites (psammoma bodies)

22
Q

What method does follicular thyroid carcinoma usually spread?

A

hematogenous

23
Q

When do MEN type II B tumors occur?

A

Infancy

24
Q

When do MEN type II A tumors occur?

A

Adolescence