Bone: Anatomy, Formation, Growth Plate Disorders, Maturation Disorders

Question 1

Significance of gray/ white marrow?

Answer 1

Pathologic, fibrotic tissue!

Question 2

Difference between haverisan canals and volkmann canals?

Answer 2

Haversian= parallel to the long axis of the bone

volkmann canals= perpendicular to the long axis of the bone

Question 3

What is organic bone matrix made of?

Answer 3

Type I collagen

Question 4

What cells produce osteoid?

Answer 4

osteoblasts

Question 5

What is the mineralization lag time?

Answer 5

12 days between when osteoid is deposited and it is mineralized

Question 6

What can inhibit osteoclastic activity?

Answer 6

calcitonin

Question 7

What is the “bone remodelling unit”?

Answer 7

Osteoblast and osteoclast

Question 8

Which bone is more rapid and less arranged…lamellar or woven?

Answer 8

woven

Question 9

What is the structure of the growth plate?

5 zones!

Answer 9

Reserve/ resting zone

Proliferative zone

Hypertrophic zone

Zone of calcification

Zone of ossification

Question 10

What is morquio syndrome?

Answer 10

mucoplysaccharide deposition in chondricytes tha leads to dwarffism , dental defects and mental retardation

Question 11

What is found in the urine of someone with morquio syndrome?

Answer 11

Keratin sulfate

Question 12

What condition results from a vitamin C deficiency?

Answer 12

Scurvy

it is a problem with collagen cross linking and osteoblastic function leading to impaired bone growth

Question 13

abnormal lateral curvature of the spine?

Answer 13

scoliosis

Question 14

abnormal anteroposterior curvature of the spine?

Answer 14

kyphosis

Question 15

One limb’s growth plate is stimulated to undergo rapid and prolonged endochorndial ossification (one limb is longer)?

Answer 15

Hemihypertrophy

Question 16

Erhlenmeyer flask deformity is associated with…

Answer 16

osteopetrosis

Question 17

Which is the mildest phenotype of OI?

Answer 17

Type I

Question 18

Which form of OI is usually fatal in utero or at birth?

Answer 18

Type II

Question 19

Which is the progressive, most severely deforming OI?

Answer 19

Type III

Question 20

What is the difference between type I and type IV OI?

Answer 20

Type IV has normal sclera (not blue)

Question 21

What us endrochromatosis?

Answer 21

tumor like masses of abnormally arranged hyaline cartilage

Question 22

What is Muffacci Syndrome?

Answer 22

Multiple enchondromas and cavernnous/ spindle cell hemangiomas

Question 23

What day after a fracture is hemorrhage and clot formation seen?

Answer 23

day 2-5

Question 24

What day after a fracture is earliest new bone seen?

Answer 24

day 7

Question 25

Reparative phase has _______ ossification.

Answer 25

endochondrial

Question 26

What is psuedoarthrosis?

Answer 26

formation of joint like tissue due to continued movement at a nonunion fracture site

Question 27

What is Legg- Calve- Perthes disease?

Answer 27

osteonecrosis in the femoral head of children

Question 28

What is fibrodysplasia ossificans?

Answer 28

massive deposits of bone around many joints

Question 29

Difference between heterotropic ossification and heterotropic calcification?

Answer 29

bone deposition vs calcium deposition outside of the skeleton

Question 30

What is myositis ossificans?

Answer 30

formation of reactive bone in muscle after injury