Bone: Anatomy, Formation, Growth Plate Disorders, Maturation Disorders Flashcards
Significance of gray/ white marrow?
Pathologic, fibrotic tissue!
Difference between haverisan canals and volkmann canals?
Haversian= parallel to the long axis of the bone
volkmann canals= perpendicular to the long axis of the bone
What is organic bone matrix made of?
Type I collagen
What cells produce osteoid?
osteoblasts
What is the mineralization lag time?
12 days between when osteoid is deposited and it is mineralized
What can inhibit osteoclastic activity?
calcitonin
What is the “bone remodelling unit”?
Osteoblast and osteoclast
Which bone is more rapid and less arranged…lamellar or woven?
woven
What is the structure of the growth plate?
5 zones!
Reserve/ resting zone
Proliferative zone
Hypertrophic zone
Zone of calcification
Zone of ossification
What is morquio syndrome?
mucoplysaccharide deposition in chondricytes tha leads to dwarffism , dental defects and mental retardation
What is found in the urine of someone with morquio syndrome?
Keratin sulfate
What condition results from a vitamin C deficiency?
Scurvy
it is a problem with collagen cross linking and osteoblastic function leading to impaired bone growth
abnormal lateral curvature of the spine?
scoliosis
abnormal anteroposterior curvature of the spine?
kyphosis
One limb’s growth plate is stimulated to undergo rapid and prolonged endochorndial ossification (one limb is longer)?
Hemihypertrophy
Erhlenmeyer flask deformity is associated with…
osteopetrosis
Which is the mildest phenotype of OI?
Type I
Which form of OI is usually fatal in utero or at birth?
Type II
Which is the progressive, most severely deforming OI?
Type III
What is the difference between type I and type IV OI?
Type IV has normal sclera (not blue)
What us endrochromatosis?
tumor like masses of abnormally arranged hyaline cartilage
What is Muffacci Syndrome?
Multiple enchondromas and cavernnous/ spindle cell hemangiomas
What day after a fracture is hemorrhage and clot formation seen?
day 2-5
What day after a fracture is earliest new bone seen?
day 7
