Endo Flashcards
What is management of Phaeochromocytoma when a patient presents unstable?
- alpha-blocker (e.g. phenoxybenzamine), given before a
- beta-blocker (e.g. propranolol)
- Surgery
What are the signs of primary hyperaldosteronism?
- Hypertension
- Hypokalaemia
On a high-dose dexamethasone suppression test, what would be suppressed in Cushing’s syndrome + give example of disease?
- ACTH
- NOT cortisol
- Adrenal adenoma
On a high-dose dexamethasone suppression test, what would be suppressed in Cushing’s disease + give example of disease?
- Cortisol + ACTH
- pituitary adenoma → ACTH secretion)
On a high-dose dexamethasone suppression test, what would be suppressed in ectopic ACTH syndrome?
Nothing
Give an example of an SGLT-2
Empagliflozin
Give an example of a sulfonylurea
Gliclazide
Give an example of a GLP-1
Liraglutide
What are signs of Cushing’s disease?
Increased glucocorticoid production:
- weight gain
- thinning skin
- abdominal striae
Lab signs
- hypokalaemic
- metabolic alkalosis.
How is hydrocortisone given in Addison’d?
The hydrocortisone dose is split with the majority given in the first half of the day
What is Exophthalmos?
Bugging of the eyes. Seein hyperthyroidism
What are complications of Subclinical hyperthyroidism?
atrial fibrillation, osteoporosis and possibly dementia
What is Goserelin + a side effect?
GnRH agonists (e.g. goserelin) used in the management of prostate cancer may result in gynaecomastia
What indicates Impaired glucose tolerance?
Impaired glucose tolerance (IGT) is defined as fasting plasma glucose less than 7.0 mmol/l and OGTT 2-hour value greater than or equal to 7.8 mmol/l but less than 11.1 mmol/l
What indicates an impaired fasting glucose?
fasting glucose greater than or equal to 6.1 but less than 7.0 mmol/l
