Embryology - Development of the face Flashcards

1
Q

When does the face begin to develop in utero?

A

4 - 8 weeks

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2
Q

When does the formation of the palate occur in utero?

A

6 - 10 weeks

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3
Q

When is the first bone laid down? Where is this bone?

A

6 - 7 weeks

Bone of the mandible

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4
Q

What are pharyngeal arches/branchial arches?

A

Outgrowths of anterior tissue bands that lie beneath the early brain.

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5
Q

How many pharyngeal arches are there?

A

Possibly 6 but 4 main.

5 can either not develop or be very short lived.

6 under debate.

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6
Q

What do each of the arches contain?

A

Cartilaginous rod - gives rise to skeletal structures

Striated muscle

A cranial nerve

A major artery

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7
Q

What does the first arch give rise to?

A

The maxillary processes

The mandibular processes/meckel’s cartilage - mandible forms around this via intramembranous ossification.

The trigeminal nerve

Muscles of mastication

Ear

Malleus

Incus

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8
Q

What cranial nerve is associated with the 2nd arch?

A

Facial nerve

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9
Q

What cranial nerve is associated with the 3rd arch?

A

The glossopharyngeal nerve

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10
Q

What cranial nerve is associated with the 4th arch?

A

The vagus nerve

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11
Q

What pharyngeal arch is the common carotid artery associated with?

A

The 3rd arch

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12
Q

What pharyngeal arch is the aortic arch associated with?

A

The 4th arch

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13
Q

What does the face develop from?

A

5 Prominences around the stomadeum (primitive mouth)

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14
Q

What are the 5 prominences that the face develops from?

A
  1. Frontonasal
  2. Medial nasal
  3. Lateral nasal

Derived from the 1st pharyngeal arch:

  1. Maxillary
  2. Mandibular
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15
Q

What does the Frontonasal prominence gives rise to?

A

(Frontonasal overlays the forebrain.)

Forehead
Bridge of nose

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16
Q

What does the medial nasal prominence gives rise to?

A

Midline of the nose
Philtrum
Primary palate

17
Q

What does the lateral nasal prominence gives rise to?

A

Alae of the nose

18
Q

What does the maxillary prominence gives rise to?

A

Maxilla
Cheeks
Lateral upper lip

19
Q

What does the mandibular prominence gives rise to?

A

Jaw
Lower lip
Chin (when 2 mandibular processes fuse)
Meckel’s cartilage

20
Q

How is the chin formed?

A

From the two mandibular processes fusing

21
Q

What causes a chin dimple?

A

When the two mandibular process partially fuse.

22
Q

What forms the primary palate?

A

The medial nasal prominence

23
Q

What forms the secondary palate/palatal shelves?

A

Maxillary process

24
Q

How do the palatal shelves grow?

A

Initially grow downwards but then rotate and fuse together.

25
Q

Where do the primary and secondary palate fuse together?

A

At the region of the incisive foramen

26
Q

How are the left and right nasal cavities formed?

A

The medial nasal prominence grows downwards along with the frontonasal prominence and fuses with the primary and secondary palate at the midline.

27
Q

What can orofacial clefts have an impact on?

A

Speaking
Feeding
Hearing - infection
Tooth developmental issues

28
Q

What are the causes of orofacial clefts?

A

Multifactorial

Environmental:
Smoking
Alcohol
Viral infection

Drugs:
Vitamin A analogues

29
Q

What is a cleft lip?

A

Failure of the maxillary prominence (palatal shelves/secondary palate) fusing to the medial nasal prominence (philtrum of lip and primary palate)

Bilateral
unilateral

30
Q

Who is most affected by cleft lip? and which side does it most commonly occur on?

A

Males

Left

31
Q

What is a cleft palate?

A

Two palatal shelves of the secondary palate (from the maxillary prominence) fail to fuse.

32
Q

Who is most affected by cleft palate and why?

A

Females - have a later elevation of the palate (week 8) whereas males palate elevates at week 7

33
Q

What bone(s) form from meckels cartilage?

A

Dorsal end = maleus and incus

Ventral end = mandible