Embryology Flashcards

1
Q

how does ectodermal proliferation start

A

once the notochord is formed, situated in the mesoderm, the cells start to release growth factors and this is called ectodermal proliferation

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2
Q

what does ectodermal proliferation lead to

A

thickening of the ectoderm in the centre which is called the neural plate

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3
Q

what happens after the ectoderm thickens

A

the edges of the neural plate come towards the centre and the centre starts pulling down. leads to folding of the neural plate

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4
Q

what is the top part of the neural plate called when it folds

A

the folds

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5
Q

what is the bottom part of the neural plate called when it starts to fold

A

the neural groove

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6
Q

when do you start seeing formation of the neural plate

A

day 17

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7
Q

when do you start seeing neural folds, groove, and differentiation into neural crest cells

A

day 18

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8
Q

where are the fused neural folds located

A

the mesoderm.

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9
Q

where are the neural crest cells located

A

where the neural folds have fused

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10
Q

when is the neural tube completely formed

A

day 21

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11
Q

what is folate needed for in this process

A

for the anterior and posterior neural pores at the cranial and caudal ends to close

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12
Q

how many mg of folate do you need per day

A

3-5mg

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13
Q

when do the anterior neural pore close

A

day 24

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14
Q

when does the posterior neural pore close

A

DAY 26

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15
Q

what does vesiculation include

A

creating three bulges, going from the cranial to caudal ends

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16
Q

what are the three bulges in order

A
  1. prosencephalon
  2. mesencephalon
  3. rhombencephalon
17
Q

what are the three bulges?

A

primary vesicles that proliferate and form more vesicles

18
Q

what does the prosencephalon split into

A
  1. telencephalon
  2. diencephalon
19
Q

what do the telencephalon and diencephalon become

A

telencephalon: cerebrum
diencephalon: thalamus and hypothalamus

20
Q

what happens to the mesencephalon

A

stays the same - doesn’t separate

21
Q

what does the mesencephalon become

A

the midbrain

22
Q

what does the rhombencephalon become

A
  1. metencephalon
  2. myelencephalon
  3. spinal cord
23
Q

what do the metencephalon and myelencephalon become

A

metencephalon: pons and cerebellum

myelencephalon: medulla

24
Q

what three layers is the caudal portion of the neural tube made up of

A
  1. marginal zone - neurones start forming
  2. mantle zone - neuroblasts
  3. neuroepithelial zone - proliferate into neuroblasts
25
Q

what is the innermost layer

A

the neuroepithelial layer

26
Q

what do the cells become at the dorsal end

A

the alar plate

27
Q

what do the cells become at the ventral end

A

the basal plate

28
Q

what will the alar plate become

A

the posterior grey horn

29
Q

what does the posterior grey horn form

A

sensory neurones

30
Q

what will the basal plate become

A

the ventral grey horn

31
Q

what does the ventral grey horn form

A

motor neurones

32
Q

what does the middle part become

A

the spinal cord which has CSF