Case 5 - Stroke recovery and rehabilitation Flashcards
stroke pathophysiology diagram
what are present on acute injury
NMDA receptors and free radicals
what produce inflammatory factors in the CNS
- astrocytes
- microglia
- neurones
what does blood brain barrier damage lead to
infiltration of neutrophils
what is responsible for the acute phase
the liver
what is angiogenesis
restoration of the blood supply
where does neurogenesis take place in the adult brain
subgranular zone of dentate gyrus of the hippocampus
sub ventricular zone in the lateral ventricle
what do you tag cells with to look at neurogenesis
3H thymidine incorporated
what happens In neurogenesis in the sub granular zone
- newly formed cells migrate from the outer sub granular zone to inner granule cell layer I the hippocampal dentate gyrus
- hippocampus is part of the memory making side of the brain
what happens in neurogenesis in the sub ventricular zone
in normal brain, neural progenitors migrate from SVZ to olfactory bulb via rostral migratory stream
what happens in neurogenesis in the sub ventricular zone in injured tissue
- neural progenitors from the SVZ leave the RMS and migrate laterally towards the damaged ares
what are the astroglia progenitors
GFAP
what are the immature proliferating cells
dcx
what are the mature neurones
NeuN
what are the factors involved in angiogenesis
cytokines
chemokine
integrins - ECM
growth factors
mediators of angiogenesis diagram
