Case 6 - Depression lecture Flashcards
what is the indicience of depression
14 per 1000 persons
what is the age of onset
24-45 years
what are the organic illnesses that can cause depression
cushings, stroke, epilepsy, hyperthyroidism
what are the genes associated with depression
what is the neuroendocrinology of depression
elevated CRF, ACTH, cortisol
decreased T4 levels
decreased levels of statin and increased growth hormone
what is there increased function of
the HPA axis
what are the abnormalities of the HPA axis in depressed patients
cortical hyper secretion
decreased glucocorticoid receptor sensitivity
abnormal circadian rhythm of cortisol
increased CSF corticotrophin releasing factor
increased circulation ACTH
increased adrenal gland size
why is achieving remission important
residual symptoms put patients at higher risk of relapse and recurrence
patients with residual symptoms after medication treatment are 3.5 times more likely to relapse compared to those fully recovered
this risk is greater than the risk associated with having more than 3 prior depressive episodes
similar findings exits after response to cognitive therapy
what is the treatment plan
