Case 5 - Medications

Question 1

what is GABA

Answer 1

an important inhibitory neurotransmitter in the brain

Question 2

what are the GABA gated chloride channels

Answer 2

GABA-A receptors are GABA gated chloride channels that mediate fast IPSPs

Question 3

what does too much inhibition result in

Answer 3

coma

Question 4

where does GABA bind

Answer 4

binds to a binding pocket between the alpha and beta subunits, causing Cl- ions to flow into the neurone, leading to a deceased chance of action potential - hyperpolarisation

Question 5

what do benzodiazepines do

Answer 5

they bind to site and act to make GABA much more effective in opening the channel and producing inhibition

Question 6

what is the strict guidance on benzenes

Answer 6

short term use only - less than.4 weeks

Question 7

where does serotonin originate from

Answer 7

the raphe nucleus of the brains ste

Question 8

what are actions of serotonin mediated by

Answer 8

G protein coupled receptors and terminated by re uptake via serotonin transporter proteins into the exon terminal

Question 9

what do SSRI’s act to do

Answer 9

to prolong the actions of released serotonin at their receptors by inhibiting reuptake

Question 10

what is an adaptive response to SSRIs

Answer 10

an increase in the glucocorticoid receptors in the hippocampus

Question 11

what may SSRI’s also dampen anxiety

Answer 11

by enhancing the feedback regulation of the CRH neurones in the hypothalamus