EBV, CMV, and Viral Latency and Cancer Flashcards

1
Q

EBV is latent in what cells and as what type of genome

A

myeloid B cells through CD21; episomal DNA in the nucleus of the infected B-cells

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2
Q

acute lytic infection

A

3-14 days, fever, fatigue, lymphadenopathy, headache, nausea, diarrhea, influenza, e bola, or norovirus

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3
Q

chronic lytic infection

A

virus continues to replicate

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4
Q

latent viral infection

A

virus does not continue to develop

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5
Q

would a sensitive test for viral particles be helpful in determining a virus in latency or in chronic infection?

A

chronic infection

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6
Q

chronic focal infection

A

cells infected with viral particle infect other cells by lysing

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7
Q

chronic diffuse infection

A

cells do not lyse but continue to replicate new cells

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8
Q

hepatitis is an example of

A

chronic lytic infection

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9
Q

both chronic and latent infections can be _____ latent; the difference is in the molecular state of the virus

A

clinically

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10
Q

provirus

A

integrated into the host genome during latency

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11
Q

episome

A

integrated into extrachromosomal DNA during latency

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12
Q

during latency both RNA and DNA viruses are stored as _____ genomes

A

DNA

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13
Q

EBV was the first

A

virus to be discovered to have a connection to cancer

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14
Q

what type of shape is EBV

A

icosahedral core

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15
Q

does EBV have a lipid envelop

A

yes

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16
Q

where does EBV get its lipid envelop

A

the host

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17
Q

herpesvirus genomes are

A

linear ds DNA

18
Q

How is EBV transmitted

19
Q

how common is EBV worldwide

A

90% of adults have the antibodies

20
Q

route of transmssion

A
  1. infects epithelial cells
  2. replicates
  3. enters the blood stream
  4. attacks B cells via CD21 complement receptor
  5. T cells keep the virus in latent state
21
Q

early clinical symptoms of EBV and then usually develop into

A

asymptomatic; mononucleosis

22
Q

clinical signs and symptoms of infectious mononucleosis

A

fatigue, fever, sore throat, lymphadenopathy

23
Q

what does mononucleosis mean

A

increased lymphocytes that are atypical

24
Q

EBV diagnosis

A

clinically diagnosed, monospot test but increased false positives and false negatives; uses heterophile antibody

25
when can you have a positive monospot test
2weeks of illness
26
EBV specific antibodies
IgM early and IgG later
27
Is acyclovir effective against CMV or EBV?
no
28
Is there a vaccine for EBV or CMV?
no
29
EBV associated diseases?
1. Burkitts lymphoma 2. Hairy leukoplakia 3. severe life threatening mono in children with x-linked lymphoproliferative syndrome
30
EBV in latency is producing what IL resulting in?
IL-10, uncontrolled proliferation
31
CMV establishes latency in
many types of cells
32
CMV is transmitted via
saliva, genital secretions, trasfusions and transplacentally
33
what is the most common cause of congenital abnormalities in the US?
CMV
34
what do you have to do before a transplant in regard to CMV?
sero match for CMV
35
what is seen on a histology stain with CMV?
giant cell formation with intranuclear inclusions that looks like an alien
36
primary infection in adults and kids are
asymptomatic
37
clinical findings with CMV
blueberry muffin lesions
38
what are the results for heterophile antibody for EBV and CMV?
positive and negative respectively
39
CMV treatment
ganciclovir and valgancyclovir
40
ganciclovir and valgancyclovir can treat
pneumonia and retinitis symptoms
41
why is ganciclovir and valgancyclovir effective and acyclovir not?
activated by cellular kinases and not HSV kinases