anti-platelet/ anti-coagulant Flashcards
1
Q
warfarin mechanism of action
A
- vitamin K antagonist
- inhibits vitamin K reductase and therefore stops the activation of vitamin K dependent zymogens
- needs bridge therapy because it only stops new vitamin K dependent zymogens from forming so there is the current storage
2
Q
warfarin antidote
A
- plasma
- vitamin K
- PCC prothrombin complex concentrate (factor II)
3
Q
why does warfarin need a bridge therapy drug?
A
- needs bridge therapy because it only stops new vitamin K dependent zymogens from forming so there is the current storage
4
Q
warfarin is contraindicated in
A
pregnant women
5
Q
warfarin side effects
A
bleeding
6
Q
How do you monitor warfarin?
A
weekly INR/PT and then monthly
7
Q
What is warfarin used to treat?
A
- prevention of stroke in a fib patients
- prevention of thrombosis in mechanical hearts and valves
- VTE
8
Q
heparin’s mechanism of action
A
binds antithrombin to inactivate factor X and thrombin
9
Q
un-fractionalized heparin must be administered
A
in the hospital
10
Q
heparins antidote
A
sulfate protamine
11
Q
low molecular weight heparin
A
enoxaparin and lovenox
12
Q
how do you monitor heparin
A
aPTT and anti-Xa levels
13
Q
how do you monitor enoxaparin (lovenox)?
A
anti-Xa levels
14
Q
mechanism of action for enoxaparin (lovenox)?
A
deactivates Xa via binding to
15
Q
what anti-coagulations are degraded by the kidney?
A
enoxaparin (lovenox) and fondaparinux
