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Pharm Part II > E4: Migrane Drugs! > Flashcards

E4: Migrane Drugs! Flashcards

1
Q

________ (5-HT) receptors are important for pain modulation

A

Serotonin

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2
Q

Serotonin receptors are found in WHAT TWO LOCATIONS?

A

Receptors are found pre-synapically and post-synaptically

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3
Q

Serotonin and Serotonergic Neurons In platelets = causes _________

A

vasoconstriction

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4
Q 
In \_\_\_\_\_\_\_\_\_\_\_\_ (PAG) = modulates nociception on a spinal level; stimulation- produced analgesia in midbrain
􏰀 Most projections from PAG are tryptaminergic
A

periaqueductal gray (PAG)

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5
Q

Serotonin and Serotonergic Neurons **modulates pain/nociception in ________ pathways

A

DESCENDING

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6
Q

Now known that ____ is involved in many behavioral and psychiatric disorders

A

5-HT

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7
Q

Data supports that migraine is caused by chronic ______ dysregulation

A

5-HT

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8
Q

______ Derivatives: ________ peripheral and cranial blood vessels

A

Ergot: Constricts

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9
Q

Ergot: Inhibits depolarization of dural blood vessel- associated ________

A

nociceptors

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10
Q

Ergot: Take ______ in onset because absorption and distribution are impaired as gastric symptoms of migraine increase. Addition of _______ speeds gastric absorption getting medication into the system more rapidly

A

early… caffeine THANK GOD

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11
Q

What are the two Ergot preps?

A

1.Ergot-amine 2.Ergot-amine and caffeine…blood vessel damage, gangrene

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12
Q

Longer half-life: chronic migraine; protracted, unresponsive migraine (in hospital care)

A

dihydro-ERGOT-amine (Migranal)

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13
Q

What was the first Triptan drug?

A

Suma-triptan

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14
Q

Selective agonists of 5-HT 1B and 5-HT 1D receptors in cranial arteries

A

Triptans

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15
Q

___________ = vasoconstrictor (like ergotamine)…acetaminophen = analgesic….dichloralphenazone = mild tranquilizing effect; central pain inhibitory effect

A

iso-meth-ept-ene (Midrin)

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16
Q

________: Phenothiazine derivatives (antipsychotics)….Control nausea and gastric irritation
with migraine….Tablet, suppository and parenteral forms….Antagonists of D2 receptors….May cause EXTRAPYRAMIDAL effects

A

AntiEmetics

17
Q

THANK YOU LITTLE WAYNE: name one AntiEmetic

A

promethazine (Phenergan, Phenadoz, Promethegan)

18
Q

What are the 8 drugs for migraine Prophylaxis?

A

5NAB-CT-CS….1. 5HT uptake inhibitors 2.NSAID 3.Antiseizure 4.Beta Blocker 5.Calcium Channel Blocker 6.Tricyclic antidepressant 7.CorticoSteroid 8.SSRI

19
Q

Treat intractable migraine that has not

responded to other interventions

A

corticosteroids

Pharm Part II (28 decks)

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