E3: AntiVirals

Question 1

What are the 3 ways you can STOP a virus?

Answer 1

1.alter UNCOATING 2.Polymerase Inhibitors 3.Inhibit protein synthesis

Question 2

What are the 2 most common indications for Interferons?

Answer 2

Hep B/C and MS

Question 3

What does “HAART” therapy stand for?

Answer 3

Highly Active AntiRetroviral Therapy

Question 4

Typical HAART cocktail: 3 types

Answer 4

1. nucleoside reverse transcriptase inhibitor, 2.non-nucleoside reverse transcriptase inhibitor and 3. a protease inhibitor

Question 5

Antiretrovirals are started for most HIV-infected patients when immunosuppression becomes pronounced….CD4 count less than _____

Answer 5

500

Question 6

What is the HIV antiFungal?

Answer 6

Amphoteracin B. should be a reflex

Question 7

nucleoside reverse transcriptase inhibitor, Must be biotransformed/________ to work

Answer 7

bioactivated

Question 8

Reverse transcriptase of HIV is ____ times more susceptible to inhibition than are normal human cells

Answer 8

1100

Question 9

Which Drugs have no effect on cells already containing HIV?

Answer 9

Nucleoside reverse transcriptase inhibitors

Question 10

AZT/Retrovir is a(n)

Answer 10

Nucleoside reverse transcriptase inhibitor

Question 11

Many oral effects: altered taste, tongue edema, bleeding gingiva, mouth ulcers

Answer 11

zidovudine (Retrovir) = “AZT”

Question 12

Do not require bioactivation

Answer 12

NONnucleoside reverse transcriptase inhibitors

Question 13

Drugs suppress viral replication by inhibiting _______, the enzyme responsible for cleaving viral precursor peptides into infective virions

Answer 13

protease

Question 14

Inhibits ______, the enzyme that helps to insert the viral cDNA strand produced by reverse transcriptase into the human genome

Answer 14

integrase

Question 15

Hiv can cause this term for “ring around the teeth”

Answer 15

linear gingival erythema