E4: LOOK GOUT! Flashcards
Gout is a form of arthritis which is caused by the accumulation of _________ in joints
uric acid crystals
Chronic gout may also cause joint destruction and decreased ______ function…It is often related to an _______ abnormality in the body’s ability to process uric acid
KIDNEY….inheritied
Uric acid is a breakdown product of _______
PURINES
The state of elevated levels of uric acid in the blood without symptoms is referred to as asymptomatic __________…a precursor state to developing gout
hyperuricemia
What are the 2 types of GOUT?
1.exessive production of uric acid 2.reduced secretion of uric acid
AVOID _______-rich foods!! Shellfish and organ meats such as liver, brains, kidneys, and sweetbreads ….AHHH no more liver?!!?
purine
AVOID 3 drinks: _______ and _____ are particularly strong factors….fructose from the corn syrup in _______ also increases the risk of gout
beer and liquor…soft drinks
_________ can be helpful in lowering the risk of recurrent attacks of gout
Weight reduction
Intensely painful condition, which mostly affects only one joint (monoarthritis) at a time, most commonly the ______
BIG TOE
Patients with longstanding hyperuricemia can have uric acid crystal deposits called _____ in other tissues as well, e.g. the helix of the ear
TOPHI—-get it TOE PHI!?
What are the 4 stages of GOUT?
1.Asymptomatic 2.Acute 3.Intercritical 4.Chronic
What drug? One indication only: treatment
of acute attack of gout…How does it work?
COL-CHICINE….CALL IN THE COLONEL!!! inhibition of neutrophil migration and phagocytic activity in inflamed joints,
What is the main side effect of colchicine?
GI toxicity
Drug: Management of chronic gout by inhibits the synthesis of uric acid….mech?
ALLO-PURIN-OL…..xanthine oxidase inhibitor that inhibits the synthesis of uric acid
What is the other indication for allopurinol that we discussed? Whats a side effect?
chemo…hepatotoxic
DRUG: Management of chronic gout by increases the excretion of uric acid = uricosuric agent
PRO-ben-ecid (for BENS future)
Low dose aspirin interferes with uricosuric action of which drug?
probenecid…dont give aspirin to BEN
What does proBENecid do to penicillin?
increases blood level of penicillin (competes for excretion)
Can NSAIDS be used to manage gout?
YES! but not with proBENacid!
