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Natsumi - NPLEX 2 > Drug Interactions > Flashcards

Drug Interactions Flashcards

1
Q

Which 2 antibiotics induce HYPOglycemia?

A
  1. Ciprofloxacin

2. Sulfamethoxazole

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2
Q

Which 2 anti-hypertensives induce HYPOglycemia?

A
  1. ACE inhibitor (Lisinopril)

2. Beta blockers (atenolol, propranolol, carvedilol)

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3
Q

Which 2 diabetes medications induce HYPOglycemia?

A
  1. Insulin

2. Glyburide

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4
Q

Which SSRI induces HYPOglycemia?

A

Fluoxetine

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5
Q

Which 2 antiretrovirals induce HYPERglycemia?

A
  1. Zidovudine

2. Adevofir

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6
Q

T/F: Prednisone is the only glucocorticoid that induces HYPERglycemia

A

FALSE! All of the glucocorticoids induce hyperglycemia

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7
Q

Which 3 types of anti-hypertensive medications induce HYPERglycemia?

A
  1. Ca channel blocker:Amlopidine
  2. Beta blockers: Atenolol and propranolol
  3. Diuretics: Furosemide (Loop) and Hydrochlorothiazide (Thiazide)
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8
Q

Which second generation (atypical) antipsychotic medication induces HYPERglycemia?

A

Risperidone

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9
Q

Which 3 lipid-lowering agent induce HYPERglycemia?

A
  1. Fish-oil (>3g daily)
  2. Atorvastatin
  3. Niacin (>2g daily)
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10
Q

Which 2 antacids deplete K+?

A
  1. Sodium bicarbonate

2. Calcium bicarbonate

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11
Q

Which 2 anti-inflammatory medications deplete K+?

A
  1. Corticosteroids

2. Aspirin

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12
Q

Which 2 diuretics deplete K+?

A
  1. Furosemide (loop)

2. Hydrochlorothiazide (thiazides)

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13
Q

Which gout medication depletes K+?

A

Colchicine

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14
Q

Which laxative medication depletes K+?

A

Bisacodyl

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15
Q

Which ACE inhibitor medication increases K+?

A

Lisinopril

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16
Q

Which angiotensin-receptor blocker medication increases K+?

A

Valsartan

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17
Q

Which 3 beta-blocker medications increase K+?

A
  1. Atenolol
  2. Propranolol
  3. Carvedilol
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18
Q

Which 2 anti-fungal medications increase K+?

A
  1. Fluconazole

2. Metronidazole

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19
Q

Which diuretic medication increases K+?

A

Spironolactone

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20
Q

Which antibiotic medication increases K+?

A

Penicillin VK

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21
Q

Which 2 anti-inflammatory medications increase K+?

A
  1. Ibuprofen

2. Naproxen

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22
Q

What are 3 other medications increase K+?

A
  1. Heparin
  2. Cyclosporine
  3. Digoxin
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23
Q

Which 3 drugs induce p-glycoprotein?

A
  1. Carbamazepine
  2. Phenytoin
  3. Phenobarbital
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24
Q

Which 4 drugs inhibit P-glycoprotein?

A
  1. Amiodarone
  2. Carvedilol
  3. Azithromycin
  4. Cyclosporine
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25
Q

Aspirin + Ibuprofen =

A

Decreased effect

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26
Q

ACE inhibitor (Lisinopril) + NSAIDS =

A
  1. Reduced effect of Lisinopril

2. Acute renal failure

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27
Q

Levodopa + Risperidone =

A

Decreased effect

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28
Q

Warfarin + Vitamin K =

A

Reduced effect of warfarin

29
Q

Beta blockers + Beta agonist (albuterol) =

A

Blocks effect, precipitate bronchospasm

30
Q

Anticholinergic drugs + acetylcholinesterase inhibitors =

A

Blocks effect

31
Q

Carbamazepine + OCPs =

32
Q

Carbamazepine + Warfarin =

A

Increased risk of coagulation

33
Q

Carbamazepine + Cyclosporine =

A

Increased dose

34
Q

NSAIDS + SSRI (Fluoxetine) or Warfarin =

A

Increased risk of bleeding

35
Q

NSAIDS + Glucocorticoids (All) =

A

Increased risk of gastric bleeding

36
Q

ACE inhibitors (Lisinopril) + Spironolactone =

A

Hyperkalemia (arrhythmia)

Renal failure

37
Q

SSRIs (Fluoxetine) + Triptans (sumatriptan) =

A

Serotonin syndrome

38
Q

SSRIs (Fluoxetine) + 5HTP, tryptophan, melatonin =

A

Serotonin syndrome

39
Q

SSRIs (Fluoxetine) + TCA (amitryptaline) =

A

Serotonin syndrome

40
Q

SSRIs (Fluoxetine) + MAO inhibitors (Phenelzine) =

A

Serotonin syndrome

41
Q

Trazodone + Buspirone =

A

Serotonin syndrome

42
Q

MAO inhibitors + amphetamines =

A

Hypertensive crisis (Sometimes fatal)

43
Q

MAO inhibitors + Sympatomimetics =

A

Hypertensive crisis (Sometimes fatal)

44
Q

MAO inhibitors + Bupropione =

A

Hypertensive crisis (Sometimes fatal)

45
Q

MAO inhibitors + Serotonergic agents (Trazodone, Fluoxetine, Sumatriptan) =

A

Hypertensive crisis (Sometimes fatal)

46
Q

Beta blockers (all) + Calcium channel blockers (Amlodipine) =

A

Serious bradycardia

47
Q

What are 2 oculotoxic responses to Isotretinoin?

A
  1. Dry eyes

2. Sudden decrease in night vision

48
Q

What is the oculotoxic response to antihistamine use?

A

Angle-closure glaucoma

s/sx: HA, eye pain, N&V, blurred vision, halo vision around lights

49
Q

What is the oculotoxic response to hydroxychloroquine?

A

Retinal toxicity leading to permanent vision loss

50
Q

What is the oculotoxic response to prednisone?

A

Cause an elevation in eye pressure, which is a major risk factor for developing glaucoma and is also associated with cataracts

51
Q

What are 3 oculotoxic responses to Sildenafil?

A
  1. Blurred vision
  2. Sensitivity to light
  3. Seeing a temporary blue tinge to objects
52
Q

What is the oculotoxic response to Tamsulosin?

A

Builds up in the iris and can prevent the pupil from dilating

53
Q

What are 2 oculotoxic responses to Amiodarone?

A
  1. Optic neuropathy/neuritis

2. Corneal micro-deposits

54
Q

What is the oculotoxic response to Tamoxifen?

A

Crystalline retinopathy

55
Q

Penicillin & Amoxicillin + Methotrexate =

A

Increase in SEs of methotrexate (N&V, mouth ulcers, low blood cell #, weakness)

56
Q

Ciprofloxacin + Theophylline =

A

Increase in SEs of theophylline (N&V, diarrhea, HA, insomnia, seizures, heart palpitations)

57
Q

Ciprofloxacin + Prednisone (and all other corticosteroids) =

A

Can increase risk of tendinitis and tendon rupture

58
Q

Ciprofloxacin + Warfarin =

A

Bleeding more easily

59
Q

Ciprofloxacin + Bupropione =

A

Can increase risk of seizure

60
Q

Ciprofloxacin + Amiodarone =

A

Can increase the risk of an irregular heart rhythm

61
Q

Ciprofloxacin + Antacids, zinc supplements, or high concentrations of multi-vitamins =

A

Reduces absorption and block effect of antibiotic

62
Q

Doxycycline + Vitamin A or Fish oil =

A

May increase risk of increased pressure in the brain

63
Q

Doxycycline + Isotretinoin =

A

May increase risk of increased pressure in the brain

64
Q

Doxycycline + Methotrexate =

A

Increase in SEs of methotrexate (N&V, mouth ulcers, low blood cell #, weakness)

65
Q

Azythromycin + Amiodarone =

A

Can increase risk of an irregular heart rhythm that is potentially life-threatening

66
Q

SMZ + Warfarin =

A

May increase risk of bleeding

67
Q

SMZ + Methotrexate =

A

Increase in SEs of methotrexate (N&V, mouth ulcers, low blood cell #, weakness)

68
Q

SMZ + Cyclosporine =

A

Can add to the risk of organ rejection

69
Q

Trimethoprim + Methotrexate =

A

Can cause suppression of bone marrow activity

Natsumi - NPLEX 2 (37 decks)

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