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Pharmakologie II > Dopaminerge System > Flashcards

Dopaminerge System Flashcards

1
Q

DA-Agonisten - Substanzen (Ergot-Derivate)

A

Bromocriptin

Cabergolin

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2
Q

MAO-B Inhibitoren - Substanzen

A

Rasagalin

Selegilin

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3
Q

COMT Inhibitoren - SUB

A

Entacapon, Tolcapon

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4
Q

Therapieschema M-Parkinson - milde Symptomatik

A

Amantadin oder MAO-B Hemmer

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5
Q

Therapieschema M-Parkinson - Initialphase

A
  1. unter 70: D-Agonist MonoTH

2. über 70: L-DOPA MonoTH

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6
Q

Therapieschema M-Parkinson - Progedienz (<70)

A

L-DOPA zusätzlich

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7
Q

Therapieschema M-Parkinson - beginnende Fluktuation

A

zstzl. COMT-Hemmer, Amantadin, MAO-B Hemmer

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8
Q

Therapieschema M-Parkinson - regellose Fluktuationen

A

tiefe Hirnstimlationen, Apomorphinpumpe, duodenales L-DOPA

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9
Q

Therapie des Ruhetremor (4)

A

Anticholinergika, Budipin, Propanolol, Clozapin

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10
Q

L-DOPA + Beserazid/Carbidopa - Probleme

A
  1. Wirkungsabnhame
  2. Motor-Fluktuationen: ON-OFF Phänomene
  3. Dyskinesien
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11
Q

L-DOPA + Beserazid/Carbidopa - UAW (4)

A

Nausea, orthostatische Hypotension, Verwirrtheit, Psychose

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12
Q

L-DOPA + Beserazid/Carbidopa - Merke

A

nicht zusammen mit proteinreicher Nahrung; 1h, Konkurrenz mit neutralen Aminosäuren

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13
Q

DA-Agonisten - UAW

A

wie L-DOPA; Ergotimus

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14
Q

MAO-B Inhibitoren - UAW

A
  1. Hypertension, höhere Herzfrequenz
  2. mit L-DOPA: orthostatische Hypotension
  3. mit SSRI: SerotoninSYN
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15
Q

COMT-Inhibitoren - IND

A

bei end of dose Fluktuationen während L-DOPA Gabe

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16
Q

COMT-Inhibitoren - UAW Tolcapan

A

Leberschädigung (= Transaminase Kontrolle)

17
Q

NMDA-Antagonisten - SUB (2)

A

Amantadin, Budipin

18
Q

NMDA - Antagonisten - UAW Budipin

A

Reservemed, weil Verlängerung der QT-Zeit

19
Q

NMDA - Antagonisten - IND (4)

A
  1. Gegen Hypokinesien (Amantadin i.v. Gabe bei akinetischer Krise)
  2. Initial vor DOPA-Gabe
  3. L-DOPA Fluktuationen
  4. L-DOPA Dyskinesien
20
Q

mAChR-Antagonisten - SUB (3)

A

Biperidon, Bornaprin, Trihexylphenidyl

21
Q

mAChR-Antagonisten - IND

A

Gegen Ruhetremor

22
Q

mAChR-Antagonisten - UAW

A

Kognitive Störungen und dann noch den typischen UAW wenn keine PARA-Kontrolle

23
Q

Tiefe Hirnstimulation

A

meist Nucleus Subthalamicus, GP –> Stimulation inhaliert die Neurone

24
Q

Spezielle Probleme bei der Parkinson Therapie

A
  1. Wirkungsfluktuationen
  2. Psychose
  3. Impulskontrollstörung
  4. Depression
  5. Demenz
  6. Orthostatsiche Hypotension
25
Q

UAW Psychose - Meds in folgender Reihenfolge weglassen

A

Anticholinergika, TCA, MAO-B Hemmer, Amantadin, Budipin, D-Agonstien, COMT-Hemmer, L-DOPA Dosis runterfahren

26
Q

L-DOPA + AAAD (2)

A

AAAD: Benserazid, Carbidopa

27
Q

Syn DA-Agonisten (Non-Ergot-Derivate) (3)

A

Parmipexol, Ropirinol, Rotigotin

Pharmakologie II (15 decks)

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