Dogs Flashcards
Scientific name of the dog
Canis lupus familiaris
Family of dogs?
Canidae
Order of dogs?
Carnivora
Most common breed of dog used in research?
beagle
Gray collies are a model for what?
cyclic hematopoiesis
Golden retrievers are a model for what?
Duchenne muscular dystrophy
What are the genetics of Duchenne muscular dystrophy?
x-linked recessive deletion of dystrophin gene
Doberman pinschers are a model for what?
hereditary canine spinal muscle atrophy; narcolepsy
Bedlington terriers are a model for what?
Copper storage dz (Wilson’s dz)
A breeder who raises all animals on their premises from a closed colony is what type of dealer?
Class A
A breeder who purchases dogs from other facilities to sell to research is what type of dealer?
Class B
Can NIH researchers use dogs from Class B dealers?
No as of 2015
What are conditioned dogs?
random-source dogs that have been treated and vaccinated in preparation for research
What is AAFCO?
Association of American Feed Control Officials
What does AAFCO do?
Advisory body that provides mechanism for feed standards
What is an open-formula diet?
defined concentration of all ingredients, info publicly available
What is a closed-formula diet?
diet that meets minimum label requirements; exact composition of ingredients may vary from batch to batch and information isn’t publicly available
What is a fixed-formula diet?
Quantitative ingredient formulation doesn’t change but info is proprietary
What is a purified diet?
Formulated from purified ingredients
How long after the mill date does feed expire?
6 mo
What age beagles have the best conception rates?
2-3.5yo
Length of gestation in dogs?
60-65d
A vaginal smear from a bitch shows intermediate and superficial cells, RBCs, and neutrophils with some anuclear squames. What stage of estrus is she most likely in?
proestrus
A vaginal smear from a bitch shows mostly anuclear squames and superficial cells. What stage of estrus is she most likely in?
estrus
A vaginal smear shows mostly intermediate cells with superficial cells, squames and neutrophils. What stage of estrus is she most likely in?
early diestrus
When a dog is in anestrus, what is seen on the vaginal cytology?
small numbers of parabasal and intermediate cells
What type of placentation do dogs have?
Endotheliochorial deciduate zonal placentation
What hormone is responsible for pregnancy maintenance in dogs?
progesterone
What effects does progesterone have during pregnancy?
endometrial gland growth, uterine milk secretion, placental attachment, inhibition of uterine motility
What is a possible predictor of impending parturition in dogs?
temperature drop to less than 100F
What is the Ferguson reflex?
Oxytocin release as a fetus engages the cervix
What are the three stages of parturition?
1- cervical dilation
2- expulsion of fetuses
3- expulsion of placenta
When should veterinary care be sought for a dog in parturition?
No pups for >5hrs or >2hrs between pups
When do puppy eyes open?
12d
When do puppy ears open?
12-20d
When are puppies weaned?
6-8w
What type of catheter is used for transcervical catheterization for intrauterine AI?
Norwegian AI catheter
What is the hormonal cause of pseudopregnancy in dogs?
Decreasing progesterone at the end of diestrus leads to clinical signs
What is the socialization period of dogs with other dogs? With people?
3-8w for other dogs
5-12w for people
Most common causes of canine infectious respiratory disease?
Bordetella bronchiseptica,
Streptococcus equi zooepidemicus,
Canine parainfluenza virus,
Canine influenza virus
Clinical signs of a mild respiratory infection?
Acute onset loud, dry, hacking cough with cough elicited on tracheal palpation
Transmission of Bordetella bronchiseptica?
Aerosoll, direct contact
Diagnosis of canine respiratory disease?
clinical signs, known history of exposure, isolation in nasal swabs
How is kennel cough treated?
reserve abx for severe/persistent infection since dz course is 10-14d regardless of tx; give supportive care +/- bronchodilators
What is the most common Group C streptococcus to infect dogs?
Strep zooepidemicus
T/F: Strep zooepidemicus is commensal in healthy dogs.
No- opportunistic pathogen
A dog dies peracutely. Necropsy reveals bulls-eye lesions on the pleural surface of affected lobes. What is your primary differential?
Strep zooepidemicus
Your facility has an outbreak of canine respiratory disease due to Strep zooepidemicus. How do you control it?
Quarantine affected dogs, disinfect fomites
What types of Leptospirosis cause renal and hepatic disease?
Canicola, Bratislava, Grippotyphosa
What types of Leptospirosis cause primarily hepatic disease?
Icterohaemorrhagiae, Pomona
What are clinical signs of acute leptospirosis in dogs?
lethargy, depression, stiffness, vx, anorexia, renal or hepatic failure
.What reproductive sequelae are associated with leptospirosis?
Abortion, stillbirth
Peracute death with interstitial nephritis with gross renal swelling, lung swelling, and hepatic foci of hemorrhage and necrosis are characteristic of what disease in dogs?
leptospirosis
What is the first-line treatment for leptospirosis?
doxycycline + aggressive fluid therapy
T/F: Most dogs are asymptomatic carriers of Campylobacter jejuni.
T.
What pathology is associated with Campy jejuni enterotoxin?
Dilated, fluid-filled bowel loops with few histo lesions
What pathology is associated with Campy jejuni cytotoxin?
friable, hemorrhagic mucosal surface with ulceration
What stain is used to visualize Campy jejuni?
Warthin-starry silver stain
How is Campylobacter diagnosed?
Culture, dark field/phase contrast microscopy
How is Listeria diagnosed?
Paired serology for surveillance, PCR for active cases
What two types of Helicobacter infect dogs?
Gastric group,
Enterohepatic group
What allows gastric Helicobacters to survive in the stomach?
Urease +
What stain is used to identify Helicobacter in dogs?
Warthin-starry silver
The urea breath test has a high specificity and sensitivity for diagnosis of what organism?
gastric Helicobacter
Carnivore protoparvovirus 1 is more commonly known as what?
Canine parvovirus strain 2
Which parvovirus strain causes disease in adult dogs?
2c
What cells does canine parvovirus have a tropism for?
rapidly dividing cells in intestine, bone marrow, lymphoid tissues
How is parvo diagnosed?
fecal ELISA; PCR for strain identification; post-mortem histology
What are characteristic histologic findings of canine parvo?
necrosis and dilation of intestinal crypt cells with secondary villous collapse
What are the three stages of rabies?
prodromal, furious, paralytic
How is rabies definitively diagnosed?
IFA of virus in negri bodies of hippocampal cells within 48hrs of death
How is Giardia diagnosed?
direct fecal smear, zinc sulfate, SNAP test (expensive and gives false positives)