Distemper Flashcards
what are some important molecular attributes that differentiate orthpmyxoviruses from paramyxoviruses?
how may the differences between orthomyxoviruses and paramyxoviruses direct microscopic pathology and viral evolution?
they will affect the localization of inclusion bodies and , in the case of orthomyxoviruses, allow for rapid evolution reassortment
what are the many and varies ways that paramyxoviruses can be diagnosed? When is one approached better than another?
ELISA
FA
PCR
-all depends on the stage of infection
what clinical signs are associated with paramyxoviruses infections and how might that relate to what you find at necropsy?
respiratory disease targeting mucosa, occasionally CNS manifestations- signs of pneumonia
how do paramyxoviruses interact with other infectious agents? what other agents may be associated with paramyxovirus infections?
they are commonly part of syndromes
-BRDC and K9 kennel cough, BVDV, IBR, BRSV, PI3, Mannheimia; Bordetella, Mycoplasma, K9 adenovirus
where does canine distemper virus paramyxoviridae replicate?
cytoplasm
describe the genome for paramyxovirdae
non-segmented
no reassortment
describe how paramyxoviruses replicate within the host
what is the pathogenesis of paramyxovirus infection?
what are the clinical signs of canine distemper virus?
what would you see microscopically from a dog infected with canine distemper virus
both cytoplasmic/intranuclear IB
how is canine distemper virus transmitted?
-aerosol via bosy fluids- even subclinical animals
-fecal- oral
-fomites , through virus relatively unstable in environment
what are there notable paramyxoviruses?
what are the differentials for respiratory diseases in feedlot cattle?
how is bovine parainfluenza virus (PI3) and respiratory syncytial viruses (BRSV) triggered
environmental conditions
stress
what is the pathogenesis for PI3 and BRSV?
what are the three categories of clinical signs for Newcastle disease virus?
- acute reps disease
- CNS signs
- diarrhea
