dermatophytes, cryptococcus, malassezia pachydermatis & Candida albicans Flashcards

1
Q

describe the dermatophyte microsporum structure

A

-spindle-shaped macroconidia
- thick walled, rough

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2
Q

describe the dermatophyte trichophyton structure

A

-cigar-shaped macroconidia
-smooth, thin walled

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3
Q

describe the structure of T. verrucosum in food animals?

A

chain chlamydospores

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4
Q

what are clinical signs of a dermatophyte infection?

A

-focal/multifocal alopecia with scaling + inflammatory “ring”
-pseudomycetomas

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5
Q

how are dermatophytes transmitted?

A

through direct contact or environmental contamination

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6
Q

how does the body react to a dermatophyte infection?

A

cell-mediated response and transient immunity
-self-limiting infection if immune system is operational

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7
Q

how can you diagnose dermatophyte infection?

A

-woods lamp
-DTM (not 100% specific for dermatophytes)

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8
Q

what is the treatment for dermatophytes?

A

topical miconazole/enilconazole

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9
Q

what are clinical presentations for dermatophyte infection?

A

skin lesions
pruritus

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10
Q

what are some differentials for a possible dermatophyte infection that is experiencing skin lesions and itching?

A

sarcastic mange, food/drug hypersensitivity, lymphoma, poxviruses

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11
Q

how are dermatophyte infections commonly resolved?

A

self-limiting (+ antifungals) in healthy animals, antifungals in immunocompromised animals

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12
Q

what is the environmental life cycle of cryptococcus gati?

A

birds and their habitat contain the yeast and the creatine in the bird droppings get into the foliag, mulch or soil and then the spores of yeast are then inhaled

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13
Q

clinical signs of cryptococcus gattii in cats?

A

nasal swelling

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14
Q

clinical signs of cryptococcus gattii in dogs?

A

CNS

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15
Q

clinical signs of cryptococcus gattii in horses?

A

respiratory

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16
Q

how do you diagnose crytococcus gattii?

A

cytology/histology

17
Q

what is the treatment for cryptococcus gattii?

A

neurological signs= bad
-long term antifungals: azoles

18
Q

how would you diagnose a case of cryptococcus in a practice?

A

microscopic examination of exudate with Diff-quick or India ink staining

19
Q

how is cryptococcus gattii transmitted and what is its life cycle in the environment?

A

environmental transmission, maintained in creatine-rich soils/foliage under trees where carrier birds have roosted

20
Q

what are the virulence factors of malassezia pachydermatis?

A

lipases
zymogens
biofilm

21
Q

what does the virulence factor lipases trigger?

A

may trigger seborrhea

22
Q

what does the virulence factor zymogens activate?

A

activate complement

23
Q

what does the virulence factor biofilm formation protect from?

A

protects from topical antifungals

24
Q

what is the common organism that is multifactorial, opportunistic and can cause canine otitis externa as well as canine seborrheic dermatitis?

A

malassezia pachydermatis

25
Q

what diagnostics can you do when suspect malassezia pachydermatis?

A

impression smears
cytology

26
Q

what is the treatment for malassezia pachydermatis?

A

-focus on underlying causes
-topical: chlorhexadine, diluted vinegar
-systemic: azoles

27
Q

what does Candida albicans cause?

A

mucosal/ GI targeted disease

28
Q

what are the virulence factors of Candida albicans?

A

adhesion
complement-binding factors

29
Q

how you do diagnose Candida albicans?

A

culture- sab. dextrose

30
Q

what is the treatment for Candida albicans?

A

focus on underlying causes

31
Q

what are the predisposing conditions for canine otitis external and what are the common organisms isolated?

A

-conditions: aural microclimate, diet, metabolic/endocrine, breed, immune disorder
-organisms: malassezia, pseudomonas, otodectes, staph

32
Q

what are the target organ systems or tissue for Candida?

A

gastrointestinal, including both upper and lower GI

33
Q

how do virulence factors help either malassezia or candida infiltrate tissue and cause clinical disease?

A

variosu enzymes like lipase and zymogens allow the organism to penetrate tissue and subsequently may trigger a severe inflammatory response

34
Q

how are diseases caused by these tow agents practically treated?

A

-alleviating predisposing conditions
-antifungals where appropriate