antiviral agents & targets Flashcards
what are the four classes of antivirals based on mechanism of action/major target?
-immunomodulators
-anti-influenza antivirals
-DNA/RNA synthesis inhibitors
-protease, integrase, and entry inhibitors
what is the objective of antivirals therapy?
inhibits viral replication while eliciting minimal toxicity to the host
what are immunomodualtors
substances that either stimulate or suppress the immune system
what are the three broad classes of anti-influenza antiviral agents?
-adamantane derivatives: ion channel blockers (amantadine, rimantadine)
-neuraminidaase inhibitors
-polymerase inhibitors
what is the mechanism of action for adamantanes?
block the uncoating step od the life cycle of influenza A viruses, traps inside endosome
-ion channel blocker
mechanism of action for neuraminidase ***
-influenza viruses express both hemagglutinin and neuraminidase
-HA binds to sialic acid on host cell
-upon replication influenza virus bud from the host cell
-viral NA cleaves dialog acid releasing viruses from membrane
give an example of neuraminidase inhibitor
oseltamivir
how do sialic acid analogs function?
function by binding to NA and preventing enzymatic activity of NA
inhibit viral release from membrane
viral treatment for parvo?
something to do/involved w bacteria in GI
how do nucleoside analogs work?
-inhibt viral DNA polymerase and have chain termination activity
-convert to triphospahte nucletotidees
where are you seeing resistance in acyclovir?
mutations to viral thymindine kinase od DNA polymease
derivatives of acyclovir
what do you use for FHV-1 ocular infection
vidarabinie
mechanism of action for Viidarabine
what is remdesivir and MOA?
MOA for cidotovir and what is it used to treat?
retroviruses
MOA of zidovudine and what used for
