Digestive System 2 Flashcards
5 Functions of the gut
- Motility
- Secretion
- Digestion
- Absorption
- Storage
What are the 2 types of gut control?
Intrinsic control and extrinsic control
What is intrinsic control?
Where the gut controls itself
What is extrinsic control?
Where the gut is controlled by an external factor outside the gut.
What are the 2 types of control that intrinsic control can have?
Neuronal = enteric nervous system
Hormonal = secretin, gastrin, CCK, GIP, Motilin
What are the 2 types of control that extrinsic control can have?
Neuronal = Vagus and Splanchnic Nerves
Hormonal = Aldosterone
Name the 4 parts of the gastrointestinal tract
- Mucosa
- Submucosa
- Tunica muscularis
- Serosa / adventitia
How is gut regulation controlled in the enteric nervous system? What are the 3 inputs?
By input from the:
- luminal receptors
- hormones
- autonomic nervous system
What is the function of the myenteric plexus?
What control is it under?
Regulates motility and muscle action
Under control of the Parasympathetic nervous system
What is the function of the submucosal plexus?
What control is it under?
Regulates local fluid and hormone release
Under control of the parasympathetic nervous system only
What are the 3 main types of luminal receptors?
Mechanoreceptors
Chemoreceptors
Osmoreceptors
What do mechanoreceptors do?
Detect stretch and stimulate contractions
What do chemoreceptors do?
Sense chemical composition of the chyme and regulate pH
What do osmoreceptors do?
Sense osmolarity and control motility and secretions
What are the 2 functional divisions of the autonomic nervous system?
Sympathetic nervous system - fight or flight
Parasympathetic nervous system - rest and digest
Two neurone pathways
Key anatomical features of the sympathetic nervous system:
- Originate at T1 - L2
- Enter the sympathetic chain
- Leave the sympathetic chain
- Synapse at prevertebral ganglia
Key functions of the sympathetic nervous system:
- slow digestive transit
- closes sphincters
- Fight or flight
Key anatomical features of the parasympathetic nervous system:
- Originate at brainstem or S-levels
- Travel to target organ - along vagus nerve
- Synapse at target
Key functions of the parasympathetic nervous system:
- Increases digestion
- Opens sphincters
- Rest and digest
How is gut regulation controlled by the autonomic nervous system?
The sympathetic nervous system:
- decreases digestive secretions
- decreases digestive motility
The parasympathetic nervous system:
- Increases rest and digest
- Increases digestive motility
what does the suffix -crine mean?
= secrete
What does endocrine mean?
= secreted into blood
What does neurocrine mean?
Secreted by nerves
What does paracrine mean?
Secreted by adjacent cells
What does autocrine mean?
Secreted by self
What is the structure of a gut endocrine cell?
- Columnar
- Narrow apex - sensory - exposed to gut lumen
- Wide base - secretory
What are the 3 phases of digestion?
- Cephalic
- Gastric
- Intestinal
What is the cephalic phase?
= in the head - Salivation
- Stimulated by parasympathetic innervation (Cranial nerves)
- Increases blood flow to glands
- Brainstem regulates visual or olfactory (response to sense of smell) salivation
What is the gastric phase?
= in stomach
- Acid production and enzyme secretion
- Sphincter relaxed
- Relaxation of stomach and duodenum - allowing entry of chyme
- Parasympathetic stimulation
- Gastrin - produced by cells in duodenum, stomach and pancreas
- Secretin produced
- Cholecystokinin produced
- Motilin produced
What is the function of Gastrin?
- Increases acid secretion
- Increases pepsinogen secretion
What is the function of Secretin?
- stimulates bile secretion
- Prevents acid secretion