Dermatopathology 1

Question 1

Diseases of epidermis

Answer 1

Pustular dermatitis
Bulbous & vesicular dermatitis
Exudative & ulcerative dermatitis
Hyperkeratotic diseases

Question 2

Diseases of dermis

Answer 2

Perivascular dermatitis
Interface & lichenoid dermatitis
Nodular dermatitis

Question 3

Pustular dermatitis

Answer 3

Pemphigus foliaceus

Question 4

Pemphigus foliaceus

Answer 4

Auto immune condition against desmoglein I cells (intercellular adhesion cell)
Targeting this cell leads to subcorneal dermatitis (LOCATION)

Question 5

Characteristic location of PF

Answer 5

Bilateral perioral, periocular, pinnae and feet distribution
Acute: pustules
Chronic: lichenified skin/thickened skin

Question 6

Differentials for acantholytic keratinocytes

Answer 6

Pemphigus foliaceous
Impetigo/pyoderma
Pustular Dermatophytosis

Question 7

Separation of epi tissue below basal layer

Answer 7

Subepidermal cleft

Question 8

Separation of epi tissue above basal layer

Answer 8

Suprabasal cleft

Question 9

Intracellular edema

Answer 9

Hydropic degeneration

Question 10

Diseases with bulbous & vesicular dermatitis - intracellular edema

Answer 10

Dermatomyosisits
Damage to basal keratinocytes

Question 11

B&V damage - intracellular edema- ballooning degeneration

Answer 11

Characteristics of contagious ecthyma — ORF

Question 12

Suprabasilar cleft

Answer 12

Pemphigus vulgaris - occurs in EQ, D&C
Oral mucosa +/- skin
Autoantibodies against desmoglein 3

Question 13

Subepidermal cleft

Answer 13

Mucous membrane pemphigoid
Bullous pemphigoid

Question 14

Mucous membrane pemphigoid

Answer 14

IgG autoantibodies targets basement membrane
Effected areas include muco membranes, oral cavity, lips, nasal planum, perinatal skin, periorbital skin, pinna

Question 15

Bullous pemphigoid

Answer 15

Targets PGlyP in basal keratinocytes
Rare
Effects head, ears, trunk —>back, axilla, abdomen

Question 16

Exudative & ulcerative dermatitis

Answer 16

Allergic dermatitis
Insect bite hypersensitivity
Eosinophilic granuloma complex

Question 17

Allergic dermatitis

Answer 17

Broad group of hypersensitive reactions
Micro lesions are usually non-responsive/specific
**use clinical data to narrow DX

Question 18

Orthokeratotic vs parakeratotic vs hyperkeratosis

Question 19

Hyperkeratotic diseases

Answer 19

Zinc responsive dermatitis
Superficial Necrolytic dermatitis

Question 20

Zinc responsive dermatosis

Answer 20

Located on face, perioral, periocular, ear tips, footpads, pressure points
Consider parakeratotic Hyperkeratotic

Question 21

Superficial Necrolytic dermatitis - hepatocutaenous snyd

Answer 21

Common pattern of HK, edema and hyperplastic cells

Question 22

Hepatocutanous syndrome

Answer 22

Honeycomb appearence/shrunk on liver
Nutrition lesion in the skin due to mal absorption in the liver

Question 23

Perivascular dermatitis

Answer 23

Surrounds blood vessel
Common non-specific pattern of dermal inflammation } Allergic dermatitis group
Eosinophil predominance – parasitic or allergic skin disease

Question 24

Interface dermatitis

Answer 24

Inflammation is secondary
Basal keratinocyte death = primary lesion } Inflammation at dermo-epidermal junction -> obscures distinction between dermis and epidermis

Question 25

Most common skin reaction

Answer 25

Perivascular disease
Non specific = least diagnostic pattern

Question 26

Interface dermatitis

Answer 26

Cell death with secondary inflammation
Common with lupus tissue reaction (discoid, systemic, ischemic derm, erythema multiforms)

Question 27

Erythema multi form e

Answer 27

Caused by
ADR
Infectious etiology
Idiopathic
Characteristic lesion:
Keratinocyte death @all layers of all skin

Question 28

Uveodermatologic dyneomes

Answer 28

Lichenodi dermatitis -
Immune mediated r targeting melanin
Bilaterally symmetric facial leukoderma letricha
=Depigmentation