Dermatopathology 1 Flashcards
Diseases of epidermis
Pustular dermatitis
Bulbous & vesicular dermatitis
Exudative & ulcerative dermatitis
Hyperkeratotic diseases
Diseases of dermis
Perivascular dermatitis
Interface & lichenoid dermatitis
Nodular dermatitis
Pustular dermatitis
Pemphigus foliaceus
Pemphigus foliaceus
Auto immune condition against desmoglein I cells (intercellular adhesion cell)
Targeting this cell leads to subcorneal dermatitis (LOCATION)
Characteristic location of PF
Bilateral perioral, periocular, pinnae and feet distribution
Acute: pustules
Chronic: lichenified skin/thickened skin
Differentials for acantholytic keratinocytes
Pemphigus foliaceous
Impetigo/pyoderma
Pustular Dermatophytosis
Separation of epi tissue below basal layer
Subepidermal cleft
Separation of epi tissue above basal layer
Suprabasal cleft
Intracellular edema
Hydropic degeneration
Diseases with bulbous & vesicular dermatitis - intracellular edema
Dermatomyosisits
Damage to basal keratinocytes
B&V damage - intracellular edema- ballooning degeneration
Characteristics of contagious ecthyma — ORF
Suprabasilar cleft
Pemphigus vulgaris - occurs in EQ, D&C
Oral mucosa +/- skin
Autoantibodies against desmoglein 3
Subepidermal cleft
Mucous membrane pemphigoid
Bullous pemphigoid
Mucous membrane pemphigoid
IgG autoantibodies targets basement membrane
Effected areas include muco membranes, oral cavity, lips, nasal planum, perinatal skin, periorbital skin, pinna
Bullous pemphigoid
Targets PGlyP in basal keratinocytes
Rare
Effects head, ears, trunk —>back, axilla, abdomen
Exudative & ulcerative dermatitis
Allergic dermatitis
Insect bite hypersensitivity
Eosinophilic granuloma complex
Allergic dermatitis
Broad group of hypersensitive reactions
Micro lesions are usually non-responsive/specific
**use clinical data to narrow DX
Orthokeratotic vs parakeratotic vs hyperkeratosis
Hyperkeratotic diseases
Zinc responsive dermatitis
Superficial Necrolytic dermatitis
Zinc responsive dermatosis
Located on face, perioral, periocular, ear tips, footpads, pressure points
Consider parakeratotic Hyperkeratotic
Superficial Necrolytic dermatitis - hepatocutaenous snyd
Common pattern of HK, edema and hyperplastic cells
Hepatocutanous syndrome
Honeycomb appearence/shrunk on liver
Nutrition lesion in the skin due to mal absorption in the liver
Perivascular dermatitis
Surrounds blood vessel
Common non-specific pattern of dermal inflammation } Allergic dermatitis group
Eosinophil predominance – parasitic or allergic skin disease
Interface dermatitis
Inflammation is secondary
Basal keratinocyte death = primary lesion } Inflammation at dermo-epidermal junction -> obscures distinction between dermis and epidermis
Most common skin reaction
Perivascular disease
Non specific = least diagnostic pattern
Interface dermatitis
Cell death with secondary inflammation
Common with lupus tissue reaction (discoid, systemic, ischemic derm, erythema multiforms)
Erythema multi form e
Caused by
ADR
Infectious etiology
Idiopathic
Characteristic lesion:
Keratinocyte death @all layers of all skin
Uveodermatologic dyneomes
Lichenodi dermatitis -
Immune mediated r targeting melanin
Bilaterally symmetric facial leukoderma letricha
=Depigmentation
