Dani - ch 6 Flashcards

1
Q

chronic inflammation

  • follows ___ inflammation
  • ____ attacks of acute inflammation
  • begins ____
A

acute
repeated
insidiously

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2
Q

immune response of chronic inflammation

- presence of 3 cells

A

macrophage
lymphocyte
plasma cells

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3
Q

phagocytosis of chronic inflammation is doen by ____ activated by gamma interferon, Ig, and complement

A

macrophages

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4
Q

repair of damage tissue from chronic inflammation done by new ___ ___ and proliferation of ___ and ___

A

blood vessels
fibroblasts
fbrosis

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5
Q

differences from acute inflammation

  • ___ onset
  • ___ course
  • vasodilation: mild (no ___ or ___)
  • scanty exudate: no ____
  • chronic inflammatory cells: __ and ___ lymphocytes, plasma cells and ____
A
insidious
progressive
redness;hotness
edema
B and T; macrophages
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6
Q

immune activation of monocytes to phagocytize

A

gamma interferon

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7
Q

non-immune activation of monocytes to phagocytize

A

bacterial endotoxin

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8
Q

morphology of monocytes in chronic inflammation

  • ___ size of cells
  • more ___ metabolism
  • more ____ enzymes
A

larger
active
lysosomal

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9
Q

monocytes are ___ cells, kills bacteria by ___ dependent and ____ mechanisms

A

scavenger
oxygen
independent

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10
Q

___ cells: produce antibodies against foreign antigens or modified tissue antigen

A

plasma

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11
Q

___: mobilized in both antibody ad cell mediated immune reactions

A

lymphocytes

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12
Q

___ lymphocytes are activated in antibody immune reactions and ___ lymphocytes are activated in cell mediated immune reactions

A

B

T

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13
Q

____: immune reaction mediated by IgE and parasitic infection

A

eosinophils

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14
Q

___: may persist in chronic inflammation

A

neutrophils

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15
Q

granulomatous chronic inflammation: presence of ____

A

granuloma

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16
Q

2 types of granulomatous chronic inflammation cells

A

epitheloid

giant

17
Q

epitheloid cells

  • essential for ___
  • are ____ macrophages
  • abundant __ ___ cytoplasm
  • elongated ____ nucleus
A

diagnosis
modified
pale pink
vesicular

18
Q

giant cells

  • ____, 40-50
  • coalescence of ___
  • __ or more nuclei
  • ___ and foreign body ___ cell
A
large
macrophages
20
langhan's
giant
19
Q

granulomatous chronic inflammation

  • central ___
  • peripheral rim of 4 cells
A
necrosis
lymphocytes
plasma cells
neutrophils
collagen fibers
20
Q

granulomatous chronic inflammation occurs in 2 types of diseases

A

infections

chemical

21
Q

non-granulomatous chronic inflammation

- ___ inflammatory cells are scattered ___ throughout the tissue

A

chronic

throughout

22
Q

___ and ___ are common in non-granulomatous chronic inflammation

A

necrosis

fibrosis

23
Q

systemic manifestation of inflammation:

- heat regulating center in ____ –> ___ stimulation –> ___ of skin vessels –> ___ heat loss –> ____

A
hypothalamus
sympathetic
vasoconstriction
decreased
fever
24
Q

fever is caused by liberation of pyrogens ___ and ___

A

IL-1 and TNF

25
Q

heat regulating center in hypothalamus act directly or by local production of ____

A

prostaglandins

26
Q

systemic manifestation of inflammation:

leukocytosis:
- immediate release from ___ ___
- prolonged infection stimulates bone marrow ___ cells

A

bone marrow

stem

27
Q

systemic manifestation of inflammation:

  • sleepiness
  • ___ blood pressure
  • ___ fibrinogen
  • __ erythrocyte sedimentation rate
A

decrease
increase
increase

28
Q

systemic manifestation of inflammation:
failure of localization (lymph involvement)
- regional lymph nodes (__ line of defense) –> failure of localization –> reticuloendothelial cells (___ line of defense)

A

2nd

3rd