1. wk 3 Reversible cellular changes accumulations (f) Flashcards
(3) categories of intracelluar accumulations that can occur
- endogenous sub.- produced at a normal rate, but metabolism rate is inadequate
- lack of enzyme
- accum. of an abnormal exogenous sub.
accum of fat in the liver is usually due to a normal endogenous sub produced, but the _______ is inadequate
rate of metabolism
c.c. Lysosomal storage dx (L.S.D): is caused by a lack of ______ needed for metab.
enzyme
c.c _____: condition where there was an inability to degrade phagocytosed particles
carbon pigment accumulation
accum of triglycerides in the cytoplasm during steatosis appear as _______
vacuoles
fatty changes are most often seen in what organ?
What is the name of this cc
liver
steatosis
(4) secondary caused to increas. syn of triglycerides in the liver
- increased fat uptake (obesity)
- excess lipolysis (diabetes, alcohol, corticosteroids)
- decreased oxidation of FA (alcohl, hypoxia, hepatotoxin
- increased syn of FA (alcohol)
(3) conditions that occur bc of alcohol abuse
- enhance lipolysis
- increas. FT synthesis
- decreas. FA oxidation
If the liver has a yellowish hue, this indicates a _______
fatty change
c.c. ______: yellow bands alternating with normal red brown uninvolved bands with heart steatonis
tabby cat
c.c.________: cholesterol accum. in smooth M cells and macrophages
atherosclerosis
c.c._____: cholesterol accum in subepithelial CT
hyperlipidemia
C.C._____: yellow plaque that forms on the skin
xanthomas
hyperlipidemia
cc.____: yellowing of the eyes
xanthelasma
hyperlipidemia
c.c_____: accum of immunoglobins in cytoplasm of malignant plasma cells (Russell bodies)
multiple myeloma
c.c. russell bodies are rounded eosinophilic bodies from ______
multiple myeloma
c.c___ accum of carbon part. of coal dust or air polution
anthracosis
_____ is the wear and tear lipochrome pigment
lipofuscin
lipofuscin is caused by degraded _________
membranes of cytoplasmic organelles
melanin is formed when tyrosinase convertes _____ into _____
tyrosine into dihydroxyphenylalanine
c.c.______: excess iron causes accum of iron
hemosiderin
(4) causes of hemosiderin
- incre. absorption of iron
- impaired iron utilization
- anemia
- blood transfusions
_____ is derived from the non iron portion of hempglobin
bilirubin
jaundice
jaundice results from (3)
- increase production due to increase destruction of RBC
- decrease excretion
- obstruction of bile flow
____ is yellowing of the sclera of the eye
icterus