1. wk 3 Reversible cellular changes accumulations (f)

Question 1

(3) categories of intracelluar accumulations that can occur

Answer 1

1. endogenous sub.- produced at a normal rate, but metabolism rate is inadequate
2. lack of enzyme
3. accum. of an abnormal exogenous sub.

Question 2

accum of fat in the liver is usually due to a normal endogenous sub produced, but the _______ is inadequate

Answer 2

rate of metabolism

Question 3

c.c. Lysosomal storage dx (L.S.D): is caused by a lack of ______ needed for metab.

Answer 3

enzyme

Question 4

c.c _____: condition where there was an inability to degrade phagocytosed particles

Answer 4

carbon pigment accumulation

Question 5

accum of triglycerides in the cytoplasm during steatosis appear as _______

Answer 5

vacuoles

Question 6

fatty changes are most often seen in what organ?

What is the name of this cc

Answer 6

liver

steatosis

Question 7

(4) secondary caused to increas. syn of triglycerides in the liver

Answer 7

1. increased fat uptake (obesity)
2. excess lipolysis (diabetes, alcohol, corticosteroids)
3. decreased oxidation of FA (alcohl, hypoxia, hepatotoxin
4. increased syn of FA (alcohol)

Question 8

(3) conditions that occur bc of alcohol abuse

Answer 8

1. enhance lipolysis
2. increas. FT synthesis
3. decreas. FA oxidation

Question 9

If the liver has a yellowish hue, this indicates a _______

Answer 9

fatty change

Question 10

c.c. ______: yellow bands alternating with normal red brown uninvolved bands with heart steatonis

Answer 10

tabby cat

Question 11

c.c.________: cholesterol accum. in smooth M cells and macrophages

Answer 11

atherosclerosis

Question 12

c.c._____: cholesterol accum in subepithelial CT

Answer 12

hyperlipidemia

Question 13

C.C._____: yellow plaque that forms on the skin

Answer 13

xanthomas

hyperlipidemia

Question 14

cc.____: yellowing of the eyes

Answer 14

xanthelasma

hyperlipidemia

Question 15

c.c_____: accum of immunoglobins in cytoplasm of malignant plasma cells (Russell bodies)

Answer 15

multiple myeloma

Question 16

c.c. russell bodies are rounded eosinophilic bodies from ______

Answer 16

multiple myeloma

Question 17

c.c___ accum of carbon part. of coal dust or air polution

Answer 17

anthracosis

Question 18

_____ is the wear and tear lipochrome pigment

Answer 18

lipofuscin

Question 19

lipofuscin is caused by degraded _________

Answer 19

membranes of cytoplasmic organelles

Question 20

melanin is formed when tyrosinase convertes _____ into _____

Answer 20

tyrosine into dihydroxyphenylalanine

Question 21

c.c.______: excess iron causes accum of iron

Answer 21

hemosiderin

Question 22

(4) causes of hemosiderin

Answer 22

1. incre. absorption of iron
2. impaired iron utilization
3. anemia
4. blood transfusions

Question 23

_____ is derived from the non iron portion of hempglobin

Answer 23

bilirubin

jaundice

Question 24

jaundice results from (3)

Answer 24

1. increase production due to increase destruction of RBC
2. decrease excretion
3. obstruction of bile flow

Question 25

____ is yellowing of the sclera of the eye

Answer 25

icterus