Dani - ch 3 Flashcards
intracellular accumulation:
normal cells may ___ abnormal amounts of various substances
accumulate
intracellular accumulation:
- accumulation of cells can be either ____ or ____
transient
permanent
intracellular accumulation:
- may be ___ or may cause varying degrees of ___
harmless
injury
intracellular accumulation:
- substances may either be in ___ or ___
cytoplasm
nucleus
intracellular accumulation:
- substances may be synthesized by ___ cell or may be produced ____
affected
elsewhere
result in abnormal intracellular accumulation can be divided into 3 types
a normal endogenous substance
lack of enzyme
accumulation of an abnormal substance
result in abnormal intracellular accumulation can be a normal endogenous substnace is produced at a normal or increase rate, but the rate of metabolism is ___ to remove
inadequate
result in abnormal intracellular accumulation can be a lack of ____ needed for metabolism of a normal or abnormal endogenous substance
enzyme
result in abnormal intracellular accumulation can be an accumulation of an abnormal ___ substance
exogenous
a normal endogenous substance (abnormal metabolism) being accumulated happens in ____ ____ in the liver
fatty tissue
a lack of enzyme being accumulated happens in ____ _____ ____ (prevents the break down of substances)
lysosomal storage disease
abnormal exogenous substance (inability to degrade phagocytosed particles) being accumulated happens in ____ or ____ ____
carbon or silica particles
____= fatty change
steatosis
___ ___ (____): accumulation of TGs in cytoplam of parenchymal cells; appear as vacuoles; reversible
fatty change
fatty change is most often seen in the ____ and may also occur in 3 other organs
liver
heart
skeletal muscle
kidney
fatty change in the liver is most commonly caused by ____
alcohol
5 other reasons for fatty change in the liver other than alcohol
obesity diabetes hypoxia hepatotoxic drugs protein malnutrition
pathogenesis of fatty change in the liver can be caused by the ___ synthesis of triglycerides secondary to ___ in fatty acids
increase
increase
alcohol can cause excess ___ and ___ synthesis of fatty acids in the liver
lipolysis
decreased
obesity can cause ___ fat intake in the liver
increased
diabetes and corticosteroids can cause excess ___ in the liver
lipolysis
hypoxia and hepatotoxins can cause ___ oxidation of fatty acids in the liver
decreased
decreased mobilization of TGs from the liver and decreased apoprotein formation in the liver can be caused by ____
malnutrition
fatty change to the naked eye in the liver looks ____, ____ and ____ and feels ___ and ___
enlarged yellow greasy soft tender
fatty change microscopically in the liver has small clear fat ___ or large single one displacing the ____
vacuole
nucleus
fatty change microscopically
- ___ of contiguous cells –> fat vacuoles unite to form a fatty ___
rupture
cyst
alcohol used __ peripheral lipolysis, ___ FA synthesis and ___ FA oxidation
enhances
increase
decrease
fatty change in the heart is due to prolonged ___ and toxic ___
hypoxia
myocarditis
fatty change in the heart has yellow bands alternating with normal red-brown uninvoled bands aka ___ ___ and feels ___ and ___ to the naked eye
tabby cat
soft flabby