Cytologie mammaire Flashcards
Écoulement du mamelon
Histiocytes
Écoulement du mamelon
Suspect de néoplasie (DCIS de HG à la biopsie)
FNA mammaire
Métaplasie apocrine
FNA mammaire
Métaplasie apocrine
Bénin (CFK)
A tightly cohesive cluster of ductal epithelial cells without atypia is noted adjacent to apocrine metaplastic cells (Papanicolaou stain).
FNA mammaire
S100+
Tumeur à cellules granulaires
FNA mammaire
S100+
Tumeur à cellules granulaires
FNA mammaire
Hyperplasie canalaire usuelle
Note the interspersed myoepithelial cells, which stand out like sesame seeds on a bun (Papanicolaou stain).
FNA mammaire
Hyperplasie canalaire atypique
In contrast to Fig. 9.5, there is less regular nuclear spacing, more overlapping, and more prominent nuclear atypia, with a suggestion of cribriform spaces. Such proliferative lesions cannot be categorized precisely by fine-needle aspiration. Histologic examination revealed atypical ductal hyperplasia bordering on noncomedo ductal carcinoma in situ (Papanicolaou stain).
FNA mammaire
Suspect de néoplasie
The cells are loosely cohesive, with marked nuclear pleomorphism, prominent nucleoli, and a dirty background. Such specimens cannot be distinguished from invasive carcinoma by fine-needle aspiration. Histologic examination revealed comedo-type ductal carcinoma in situ (Papanicolaou stain).
FNA mammaire
Fibroadénome
FNA mammaire
Fibroadénome
Branching antler-horn clusters are the predominant arrangement of cells. There are rare stripped naked nuclei and bipolar cells in the background, but they are not prominent in this case, making it difficult to distinguish from a ductal proliferative process (Romanowsky stain).
FNA mammaire
Fibroadénome
Clusters of tightly cohesive cells with minimal nuclear atypia are characteristic of fibroadenomas (Romanowsky stain).
FNA mammaire
Fibroadénome
FNA mammaire
Fibroadénome
Note the presence of nuclear atypia and prominent nucleoli. The tightness of the cluster is an important clue for avoiding an overdiagnosis of malignancy (Papanicolaou stain).
FNA mammaire
Patiente jeune
Changements de lactations
Cells in loose clusters can also be seen. Nuclei are round or oval, with prominent nucleoli (Thinprep, Papanicolaou stain).
FNA mammaire
Patiente jeune
Changements de lactation
Numerous stripped (“naked”) nuclei are seen
FNA mammaire
Nécrose adipeuse
Necrotic fat is recognized by the absence of fat cell nuclei. In the early stage there is neutrophilic infiltration, as seen here; later stages demonstrate numerous foamy macrophages (lipophages)
Cryptococcose
There are numerous intracellular yeast forms within macrophages (hematoxylin and eosin stain).
FNA mammaire
Adénocarcinome mammaire
The cells are finely vacuolated and resemble
histiocytes, but there is nuclear atypia and an increased nuclear-to-cytoplasmic ratio (Papanicolaou stain).
FNA mammaire
Antécédent de néoplasie
Changements post-radiques
FNA mammaire
Antécédent de néoplasie
Adénocarcinome
In contrast to Fig. 9.16, the nuclei are irregular in contour, and the nuclear-to-cytoplasmic ratio is increased (Thinprep, Papanicolaou stain).
FNA mammaire
Homme
Gynécomastie
Cohesive flat sheets are identical to those of fibroadenoma and ductal proliferative processes (Papanicolaou stain).
FNA mammaire
Homme
Gynécomastie
Cohesive flat sheets are identical to those of fibroadenoma and ductal proliferative processes (Papanicolaou stain).
FNA mammaire
Lésion papillaire (ici papillome intra-canalaire)
FNA mammaire
Lésion papillaire (ici carcinome papillaire encapsulé)
FNA mammaire
Carcinome micro-papillaire
Well-differentiated neoplasms like this invasive micropapillary carcinoma can be very difficult to diagnose (Thinprep, Papanicolaou stain).
FNA mammaire
Même chose
Tumeur phyllode
(A) Similar cytologically to a fibroadenoma, a phyllodes tumor has greater cellularity. (B) The difference between stromal and epithelial cells is subtle and can be obscured in a liquid-based preparation (Thinprep, Papanicolaou stain).
FNA mammaire
Même chose
Tumeur phyllode
Figure 09-23B.Phyllodes tumor. (A) Epithelial clusters in a phyllodes tumor resemble those of fibroadenoma but may be more crowded (Romanowsky stain). (B) Stromal clusters can be very cellular (Papanicolaou stain).
FNA mammaire
Malin
Tumeur phyllodes malignes
FNA mammaire
Adénocarcinome canalaire
A major criterion for the diagnosis of ductal carcinoma is a highly cellular specimen. Even at low magnification, nuclear atypia is prominent (Romanowsky stain).
FNA mammaire
Adénocarcinome canalaire
The specimen is very cellular, and the cells are dispersed both as isolated cells and as loosely cohesive clusters (Papanicolaou stain).
Lésion cellulaire
FNA mammaire
Many of the isolated cells of ductal cancers are comet-shaped, with a nucleus that protrudes from the cytoplasm. Whether or not there is marked nuclear atypia, a protuberant nucleus suggests carcinoma (Thinprep, Papanicolaou stain).
FNA mammaire
Note the pronounced nuclear pleomorphism and atypia, apparent with both the Romanowsky (A)
FNA mammaire
Adénocarcinome mammaire
Note the pronounced nuclear pleomorphism and atypia, apparent with the Papanicolaou (B) stains.
FNA mammaire
Adénocarcinome mammaire
The tumor cells are buried in a background of marked acute inflammation. In samples with abundant acute inflammation, a careful search must be conducted to exclude malignant cells (Papanicolaou stain).
FNA mammaire
Adénocarcinome mammaire variante lobulaire
(A) a loose, single-file arrangement is apparent.
FNA mammaire
Carcinome mammaire variante lobulaire
(B) Large, solitary intracytoplasmic vacuoles are present, imparting a signet-ring cell appearance (Papanicolaou stain).
FNA mammaire
LCIS
The cells are present in loosely cohesive sheets (Papanicolaou stain).
In contrast with Fig. 9.31, the cells are dispersed, and signet-ring cell forms are noted. Such a case is likely to be overdiagnosed as invasive lobular carcinoma (Papanicolaou stain).
FNA mammaire
Carcinome médullaire
The cells are very large, with prominent nucleoli and frequent mitoses (hematoxylin and eosin stain).
Lymphocytes and plasma cells are often noted in the background (hematoxylin and eosin stain).
FNA mammaire
Même chose
Adénocarcinome mucineux
FNA mammaire
Adénocarcinome de bas-grade (tubulaire)
FNA mammaire
Carcinome (ici métaplasique)
Isolated highly atypical spindle cells are noted (Romanowsky stain).
FNA mammaire
Carcinome apocrine
FNA mammaire
Carcinome adénoïde kystique
FNA mammaire
Carcinome adénoïde kystique
FNA mammaire
Implant mammaire
Breast Implant–Associated Anaplastic Large Cell Lymphoma. (a) Large atypical lymphoid cells have prominent nucleoli (cytocentrifuge preparation, Romanowsky stain). (B) The excised implant reveals neoplastic cells surrounding the capsule (hematoxylin and eosin stain).
FNA mammaire
SCNEC
