Cytokines

Question 1

TH1 secrete

Answer 1

IL-2
IL-3
IFN gamma
TNF alpha 
TNF beta
GM-CSF

Question 2

TH2 cells secrete

Answer 2

IL-4
IL-5
IL-6
IL-10
IL-13
IL-9

Question 3

TH1 function

Answer 3

Cytotoxicity and delayed hypersensitivity

Question 4

TH2 function

Answer 4

B cell activation and stimulation of IgG and IgE secretion

Question 5

Proinflammatory cytokines

Answer 5

IFN
TNF
IL-1
IL-6
IL-18

Question 6

Immune cytokines (responsible for development, production, growth, differentiation of lymphocytes)

Answer 6

IL-2
IL-4
IL-9
IL-13

Question 7

Immune-mediated inflammation cytokines

Answer 7

IFN gamma
IL-5
IL-12

Question 8

Blood forming cytokines

Answer 8

G-CSF (lineage specific)
GM-CSF (non-specific)
IL-11

Question 9

Roeferon A

Answer 9

IFN alpha 2a

Try: chronic myeloid leukemia, kaposi sarcoma, hairy cell leukemia, hep B and C

Question 10

Intron A

Answer 10

IFN alpha 2a

Trt: hairy cell leukemia, condylomata, acuminata, chronic hep non-A, non-B or C

Question 11

Enbrel

Answer 11

Binds to TNF alpha and inactivates it

Trt: RA, juvenile RA

Question 12

Kineret

Answer 12

IL-1 RECEPTOR antagonist

Trt: active RA

Question 13

Proleukin

Answer 13

IL-2

Trt: cancer (generation of LAK), AIDS, bone marrow transplant

Question 14

Denileukin diftitox

Answer 14

IL-2 and diphtheria toxin

Trt: cutaneous T cell lymphoma

Question 15

Actimmune

Answer 15

IFN gamma

Trt: osteoporosis, chronic granulomatous disease

Question 16

Filgrastim

Answer 16

G-CSF (neutrophils)

Trt: pts receiving cytotoxic chemotherapy

Question 17

Sargramostim

Answer 17

GM-CSF

Trt: bone marrow function in chemotherapy and cancer

Question 18

Oprelvekin

Answer 18

IL-11

Trt: induce platelet production