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Pharmacy Drugs > 416 Chemotherapy > Flashcards

416 Chemotherapy Flashcards

1
Q

Chemotherapy agents

A 
Antimetabolites 
Microtubule targeting agents 
Topoisomerase active agents 
Alkylating agents 
Miscellaneous agents
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2
Q

Antimetabolites

A

Cytarabine
Fluorouracil
Methotrexate

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3
Q

Class toxicities of antimetabolites

A

Myelosuppression

Diarrhea

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4
Q

Antimetabolite: Cytarabine DLT and HMT

A

DLT/HMT: cerebellar syndrome from high dose

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5
Q

Antimetabolite: Fluorouracil DLT and HMT

A

DLT/HMT: stomatitis and diarrhea

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6
Q

Enhances activity AND toxicity of 5FU

A

Leucovorin

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7
Q

Antimetabolite: Methotrexate DLT and HMT

A

DLT: myelosuppression, mucositis, diarrhea
HMT: myelosuppression, mucositis, diarrhea, nephrotoxicity

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8
Q

DDI with methotrexate

A

Bactrim
NSAID
PPI (?)

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9
Q

Given with MTX 24-36hrs pose dose

A

Leucovorin

-use with MTX doses >500

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10
Q

Drug used for MTX toxicity caused by renal toxicity

A

Glucarpidase

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11
Q

Microtubule-targeting agents

A

Paclitaxel
Docetaxel
Vincristine

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12
Q

Microtubule-targeting agents class SE

A

Peripheral neuropathy

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13
Q

Microtubule: Paclitaxel DLT and HMT

A

DLT: peripheral neuropathy
HMT: complete alopecia

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14
Q

Microtubule: Docetaxel DLT and HMT

A

HMT: edema

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15
Q

Microtubule: Vincristine DLT and HMT

A

DLT/HMT: peripheral neuropathy

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16
Q

Topoisomerase inhibitors

A

Doxorubicin

Irinotecan

17
Q

Topoisomerase: Doxorubicin DLT and HMT

A

DLT/HMT: delayed cardiotoxicity (yrs after taking the agent)
Max accumulated dose: 450-550 mg/m2

18
Q

Topoisomerase: Irinotecan DLT and HMT

A

DLT/HMT: delayed diarrhea (>12-24hrs post dose)

-loperamide 4mg at onset and 2mg q2h until resolution

19
Q

Alkylating agents

A

Cyclophosphamide

Ifosfamide

20
Q

Alkylating agents class SE

A

Sterility/infertility/teratogenic

Carcinogenic (leukemia, myelodysplastic syndrome)

21
Q

Alkylating: Cyclophosphamide DLT and HMT

A

HMT: hemorrhagic cystitis

-trt with Mesna

22
Q

Alkylating: Ifosfamide DLT and HMT

A

HMT: hemorrhagic cystitis

23
Q

Platinum: Cisplatin and Carboplatin DLT and HMT

A

HMT: nausea, vomiting

24
Q

Platinum: Oxaliplatin DLT and HMT

A

DLT/HMT: peripheral neuropathy

25
Q

Anti-angiogenesis: Thalidomide DLT and HMT

A

HMT: teratogenicity

26
Q

Corticosteroids

A

Prednisone

Dexamethasone

27
Q

SE of corticosteroids

A

Insomnia, fluid retention, nausea, increased appetite, irritability, hyperglycemia

28
Q

Immune therapies

A

PegIFN

IL-2

29
Q

PegIFN SE

A

Flu-like symptoms

Neurologic toxicities

30
Q

IL-2 SE

A

Hypotension, fluid retention, acute renal dysfunction
GI hemorrhage, stomatitis
Capillary leak syndrome (high dose)

31
Q

Targeted therapy agents

A

Histone deacetylase inhibitors
PARP inhibitors
Proteasome inhibitors

32
Q

Histone: Panobinostat DLT and HMT

A

HMT: QT prolongation

33
Q

PARP: Olparib SE

A

Anemia, nausea, increased SCr, AML/MDS

34
Q

Proteasome: Bortezomib DLT and HMT

A

DLT/HMT: peripheral neuropathy

Pharmacy Drugs (37 decks)

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