Antibiotics MOA Flashcards by Miriam Opara

Q

Cycloserine

A

Cell Wall Synthesis

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Q

Vancomycin

A

Cell Wall Synthesis

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Q

Bacitracin

A

Cell Wall Synthesis

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Q

Fosfomycin

A

Cell Wall Synthesis

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Q

Penicillins

A

Cell Wall Synthesis

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Q

Cephalosporins

A

Cell Wall Synthesis

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Q

Monobactams

A

Cell Wall Synthesis

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Q

Carbapenems

A

Cell Wall Synthesis

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Q

Cell Wall Synthesis

A

Cycloserine
Vancomycin
Bacitracin
Fosfomycin
Penicillins
Cephalosporins
Monobactams
Carbapenems

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Q

Polymyxins

A

Cell Membrane

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Q

Cell Membrane

A

Polymyxins

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Q

Trimethoprim

A

Folic Acid Metabolism

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Q

Sulfonamides

A

Folic Acid Metabolism

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Q

Folic Acid Metabolism

A

Trimethoprim

Sulfonamides

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Q

Nalidixic Acid

A

DNA Replication (Gyrase)

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Q

Quinolones

A

DNA Replication (Gyrase)

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Q

DNA Replication (Gyrase)

A

Nalidixic Acid

Quinolones

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Q

Rifampin

A

DNA-dependent RNA Polymerase

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Q

DNA-dependent RNA Polymerase

A

Rifampin

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Q

Erythromycin

A

Protein Synthesis (50s Inhibitor)

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Q

Chloramphenicol

A

Protein Synthesis (50s Inhibitor)

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Q

Clindamycin

A

Protein Synthesis (50s Inhibitor)

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Q

Protein Synthesis (50s Inhibitor)

A

Erythromycin
Chloramphenicol
Clindamycin
Linezolid

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Q

Tetracycline

A

Protein Synthesis (30s Inhibitor)

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Q

Spectinomycin

A

Protein Synthesis (30s Inhibitor)

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Q

Streptomycin

A

Protein Synthesis (30s Inhibitor)

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Q

Gentamicin/Tobramycin

A

Protein Synthesis (30s Inhibitor)

Q

Amikacin

A

Protein Synthesis (30s Inhibitor)

Q

Protein Synthesis (30s Inhibitor)

A

Tetracycline
Spectinomycin
Streptomycin
Gentamicin/Tobramycin
Tigecycline

Q

All abx side effects

A

Allergy

C diff

Q

Beta lactams side effect

A

Neutropenia
Thrombocytopenia
Seizures

Q

Nafcillin side effect

A

Thrombophlebitis

Neutropenia

Q

Ceftriaxone side effect

A

Biliary sludge formation

Q

Macrolides side effect

A

GI upset
Thrombophlebitis
P450 inhibitor
Bone marrow suppression

Q

AGs side effect

A

Nephrotoxicity
Ototoxicity
Neuromuscular blockade

Q

Vanco side effect

A

Nephrotoxicity
Ototoxicity
Neuromuscular blockade

Q

FQN side effect

A

Phototoxicity 
CNS side effect
QT prolongation 
Hypo/hyperglycemia 
Al/Ca/Mg ion interactions

Q

Tetracycline side effect

A

N/V, diarrhea
Phototoxicity
CNS side effect
Al/Ca/Mg ion interactions

Q

Tigemycin side effect

A

N/V/diarrhea
Phototoxicity
CNS side effect
Al/Ca/Mg ion interactions

Q

Daptomycin side effect

A

Elevated CPK

Q

Linezolid side effect

A

Thrombocytopenia
Optic neuritis
Serotonin syndrome

Q

Clindamycin side effect

A

N/V/D

Q

Metronidazole side effect

A

Metallic taste

P450 inhibitor

Q

G+ resistance mechanism

A

Change PBPs
Beta-lactamases
Efflux pump

Q

G- resistance mechanisms

A

Beta-lactamases
Efflux pump
Enzyme mediated degradation
Change membrane permeability

Q

Macrolide that is NOT P450 inhibitor

A

Azithromycin

Q

Linezolid

A

Protein Synthesis (50s)

Q

Metronidazole

A

DNA Synthesis

Q

Broad spectrum PCNs

A

Amoxicillin

Ampicillin

Q

Narrow Spectrum PCNs

A

PCN G

PCN V

Q

Penicillinase-resistant PCNs (anti-staph PCNs)

A

Cloxacillin
Naficillin
Dicloxacillin
Oxacillin

Q

Extended-spectrum PCN (anti-pseudomonas PCNs)

A

Piperacillin

Ticacillin

Q

Beta-lactamase inhibitors

A

Clavulanic acid
Sulbactam
Tazobactam

Q

G+ activity Cephalosporins

A

First gen

Q

First generation Cephalosporins

A

Cephalexin
Cephalothin
Cephradine
Cefazolin 
Cefadroxil

Q

G- activity Cephalosporins

A

2-4 gen increasing

Q

Second gen Cephalosporins

A

Cefuroxime
Cefamandole
Cefaclor
Cefaranide 
Cefoxitin
Cefotitan

Q

Third gen Cephalosporins

A

Cefotaxime 
Ceftriaxone 
Cefodizime*
Ceftizoxime*
Ceftazidime*
Cefoperazone* 
*anti-pseudomonas activity

Q

Fourth gen Cephalosporins

A

Cefepime

Q

Broad spectrum beta-lactams last resort

A

Carbapenems:
Ertepenam
Imipenam
Meropenam

Q

Monobactams

A

Aztreonam

Q

Broad spectrum abx

A

Carbapenams
Chloramphenicol 
2-4 gen cephalosporin 
FQ
Broad spectrum PCNs
Tetracycline 
Sulfonamides

Q

Narrow spectrum abx

A

PCN G and V
Clindamycin
Vancomycin (only G+)
Daptomycin

Q

Carbapenem that doesn’t cover pseudomonas

A

Ertapenam

Q

Telavancin side effect

A

Teratogenic

QT elongation

Q

DDI with ritonavir because it has ethanol in it (disulfiram)

A

Metronidazole