CV 3 cerebrovascular disease Flashcards
neurological deficit secondary to abnormal perfusion of brain tissue
stroke
permanent cerebrovascular disease
stroke
syncope has many causes and most cases resolve in –
one hour
stroke is the – cause of death
2nd
rate of stroke and TIA doubles after the age of –
55
ethnicity risk
twice for African Americans and Hispanics compared to whites
HTN increases risk
4x
diabetes and smoking increases risk
2x
can oral contraceptives increase risk?
yes
most strokes are
ischemic
transient loss of consciousness caused by a global decrease in cerebral perfusion
TIA
Cardiac syncope has the same causes as –
ischemic stroke (reduced CO)
– syncope may be preceded by autonomic symptoms like nausea, sweating, light-headedness
vasovagal
dehydration reduces intravascular volume leading to –
orthostatic syncope
reproducible vasovagal syncope caused by forceful urination, defecation, coughing
situational syncope
large artery stenosis
internal carotid, vertebral, basilar, branches of circle of Willis
in addition to larger artery stenosis, cardiac emboli, and small vessel disease what are other causes of ischemic stroke?
sickle cell disease hypercoagulable states drugs birth control pills (compromise blood flow)
small vessel disease is characterized by –
endothelial damage (small lacunar infarcts in deep brain)
subarachnoid hemorrhage involves bleeding into the subarachnoid spaces and –
cerebrospinal fluid
intracerebral hemorrhage involves rupture of arteries and bleeding in the –
brain parenchyma
diffuse hemorrhage
subarachnoid
focal hemorrhage
intracerebral
caused by aneurysms, vascular malformation, trauma, DIC
subarachnoid hemorrhage
caused by hypertensive hemorrhage, use of anticoagulants esp in older patients
intracerebral hemorrhage
brain is supplied with –
14% of CO
brain utilizes –
10% of blood glucose
most commonly affected artery for focal ischemia?
middle cerebral artery
may initially see occipital headache, unsteady gait, ataxia, nausea and vomiting
hemorrhagic stroke
differentiates between ischemic and hemorrhagic strokes
CT scan
first line diagnostic test for ischemia
CT scan
sensitive for detecting early ischemia
MRI
MRI is used to see relationship with –
surrounding tissues
perfusion scanning that shows under-perfused areas
MRI
gold standard for diagnosing ischemia
cerebral angiography
cerebral angiography evaluates –
large intracranial and extracranial blood vessels
shows changing blood flow with neural activity
fMRI
real time test to see which parts of brain are active
fMRI
purpose of non-contrast CT
differentiate ischemic and hemorrhagic stroke
although t-PA is the main treatment of ischemic stroke, newer therapies include
angioplasty and stenting (catheter-based therapies)
evidence suggest that – is superior to medical treatment in cases of greater than 70% stenosis associated with symptoms such as TIAs
surgical carotid endarterectomy
carotid endarterectomy removes – from carotid artery to restores blood flow to brain
atherosclerotic plaque