Adrenergic agonists

Question 1

adrenergic receptor agonists are – drugs

Answer 1

sympathomimetic

Question 2

what type of receptor are adrenergic receptors?

Answer 2

G-protein coupled

Question 3

adrenergic receptor’s structure

Answer 3

7 transmembrane segments

Question 4

dopamine as a – also activates adrenergic receptors

Answer 4

catecholamine

Question 5

catecholamines are monoamines, organic compounds that have a – (benzene with two hydroxyl side groups) and a side chain amine

Answer 5

catechol

Question 6

example of a synthetic catecholamine

Answer 6

levonordefrin

Question 7

only catecholamine that doesn’t discriminate between adrenoreceptor subtypes

Answer 7

EPI

Question 8

catecholamines are released from –

Answer 8

postganglionic sympathetic terminal and adrenal glands

Question 9

after its release, catecholamines act on –

Answer 9

postsynaptic receptors or directly into circulation

Question 10

albuterol

Answer 10

direct acting noncatecholamine

Question 11

receptors for albuterol

Answer 11

beta 2

Question 12

clonidine

Answer 12

direct acting noncatecholamine

Question 13

phenylephrine

Answer 13

direct acting noncatecholaimine

Question 14

receptors for clonidine

Answer 14

alpha 2

Question 15

receptors for phenylphrine

Answer 15

alpha 1

Question 16

function of indirect acting noncatecholamine

Answer 16

cause NE release or blocks reuptake

Question 17

alpha and beta 1

Answer 17

NE and tyramine and amphetamine

Question 18

tyramine

Answer 18

indirect acting noncatecholamine

Question 19

receptors for tyramine

Answer 19

alpha and beta 1

Question 20

receptors for amphetamine

Answer 20

alpha (CNS) and beta 1

Question 21

mixed acting noncatecholamine

Answer 21

ephedrine

Question 22

receptors for ephedrine

Answer 22

alpha (CNS), beta, NE release

Question 23

not effective orally

Answer 23

catecholamine

Question 24

no direct effects on CNS

Answer 24

catecholamine

Question 25

short acting

Answer 25

catecholamine

Question 26

many are effective orally

Answer 26

noncatecholamine

Question 27

many have effects on CNS

Answer 27

noncatecholamine

Question 28

many are longer acting

Answer 28

noncatecholamine

Question 29

many are more selective in action

Answer 29

noncatecholamine

Question 30

chemical properties of catecholamines

Answer 30

polar and aqueously soluble

Question 31

receptors for isoproterenol

Answer 31

beta 1, beta 2

Question 32

receptors for dobutamine

Answer 32

beta 1

Question 33

receptors for levonordefrin

Answer 33

alpha 2, beta 1

Question 34

-- receptors are close to sites of NE release from postganglionic neuron vasicosities

Answer 34

alpha 1

Question 35

exogenously administered sympathomimetics or EPI/NE released from adrenal glands will affect the post junctional -- receptors that sit outside the varicosities

Answer 35

alpha 2

Question 36

catecholamines are not effective orally because they are -- and will dissolve in water

Answer 36

polar compounds

Question 37

catecholamines are not effective orally because they are inactivated by --

Answer 37

digestive enzymes

Question 38

if catecholamines are given -- or gingival retraction cord catecholamine, (if not broken down by enzymes) will be rapidly absorbed by the oral tissues and induce their effects

Answer 38

sublingually

Question 39

why do catecholamines have no direct central effects?

Answer 39

polar so they can't cross blood brain barrier

Question 40

why are catecholamines short acting?

Answer 40

efficient reuptake; metabolic breakdown

Question 41

why are non-catecholamines effective orally?

Answer 41

non-polar

Question 42

why are non-catecholamines effective in CNS?

Answer 42

can cross blood brain barrierf

Question 43

serotonin and NE reuptake inhibitor antidepressants exhibit exaggerated response at --

Answer 43

synaptic clefts

Question 44

serotonin and NE reuptake inhibitor antidepressants lead to --

Answer 44

greater amounts of NE in synapse = happiness

Question 45

tricyclics

Answer 45

antidepressant

Question 46

what are tricyclics used for?

Answer 46

pain management

Question 47

selective serotonin reuptake inhibitors

Answer 47

antidepressant

Question 48

serotonin-NE reuptake inhibitors

Answer 48

antidepressant

Question 49

what are serotonin-NE reuptake inhibitors used for?

Answer 49

pain management

Question 50

monoamine oxidase inhibitors

Answer 50

antidepressant

Question 51

trazadone and remeron are antidepressant used for --

Answer 51

sleep aides

Question 52

two marketed drugs that are COMT inhibitors

Answer 52

entacapone and tolcapone

Question 53

function of COMT inhibitors in Parkinson patients?

Answer 53

prevent l-Dopa metabolism to dopamine (as well as inhibit EPI/levonordefrin metabolism)