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Systems 1 > Adrenergic agonists > Flashcards

Adrenergic agonists Flashcards

1
Q

adrenergic receptor agonists are – drugs

A

sympathomimetic

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2
Q

what type of receptor are adrenergic receptors?

A

G-protein coupled

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3
Q

adrenergic receptor’s structure

A

7 transmembrane segments

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4
Q

dopamine as a – also activates adrenergic receptors

A

catecholamine

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5
Q

catecholamines are monoamines, organic compounds that have a – (benzene with two hydroxyl side groups) and a side chain amine

A

catechol

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6
Q

example of a synthetic catecholamine

A

levonordefrin

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7
Q

only catecholamine that doesn’t discriminate between adrenoreceptor subtypes

A

EPI

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8
Q

catecholamines are released from –

A

postganglionic sympathetic terminal and adrenal glands

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9
Q

after its release, catecholamines act on –

A

postsynaptic receptors or directly into circulation

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10
Q

albuterol

A

direct acting noncatecholamine

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11
Q

receptors for albuterol

A

beta 2

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12
Q

clonidine

A

direct acting noncatecholamine

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13
Q

phenylephrine

A

direct acting noncatecholaimine

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14
Q

receptors for clonidine

A

alpha 2

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15
Q

receptors for phenylphrine

A

alpha 1

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16
Q

function of indirect acting noncatecholamine

A

cause NE release or blocks reuptake

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17
Q

alpha and beta 1

A

NE and tyramine and amphetamine

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18
Q

tyramine

A

indirect acting noncatecholamine

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19
Q

receptors for tyramine

A

alpha and beta 1

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20
Q

receptors for amphetamine

A

alpha (CNS) and beta 1

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21
Q

mixed acting noncatecholamine

A

ephedrine

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22
Q

receptors for ephedrine

A

alpha (CNS), beta, NE release

23
Q

not effective orally

A

catecholamine

24
Q

no direct effects on CNS

A

catecholamine

25
Q

short acting

A

catecholamine

26
Q

many are effective orally

A

noncatecholamine

27
Q

many have effects on CNS

A

noncatecholamine

28
Q

many are longer acting

A

noncatecholamine

29
Q

many are more selective in action

A

noncatecholamine

30
Q

chemical properties of catecholamines

A

polar and aqueously soluble

31
Q

receptors for isoproterenol

A

beta 1, beta 2

32
Q

receptors for dobutamine

A

beta 1

33
Q

receptors for levonordefrin

A

alpha 2, beta 1

34
Q

– receptors are close to sites of NE release from postganglionic neuron vasicosities

A

alpha 1

35
Q

exogenously administered sympathomimetics or EPI/NE released from adrenal glands will affect the post junctional – receptors that sit outside the varicosities

A

alpha 2

36
Q

catecholamines are not effective orally because they are – and will dissolve in water

A

polar compounds

37
Q

catecholamines are not effective orally because they are inactivated by –

A

digestive enzymes

38
Q

if catecholamines are given – or gingival retraction cord catecholamine, (if not broken down by enzymes) will be rapidly absorbed by the oral tissues and induce their effects

A

sublingually

39
Q

why do catecholamines have no direct central effects?

A

polar so they can’t cross blood brain barrier

40
Q

why are catecholamines short acting?

A

efficient reuptake; metabolic breakdown

41
Q

why are non-catecholamines effective orally?

A

non-polar

42
Q

why are non-catecholamines effective in CNS?

A

can cross blood brain barrierf

43
Q

serotonin and NE reuptake inhibitor antidepressants exhibit exaggerated response at –

A

synaptic clefts

44
Q

serotonin and NE reuptake inhibitor antidepressants lead to –

A

greater amounts of NE in synapse = happiness

45
Q

tricyclics

A

antidepressant

46
Q

what are tricyclics used for?

A

pain management

47
Q

selective serotonin reuptake inhibitors

A

antidepressant

48
Q

serotonin-NE reuptake inhibitors

A

antidepressant

49
Q

what are serotonin-NE reuptake inhibitors used for?

A

pain management

50
Q

monoamine oxidase inhibitors

A

antidepressant

51
Q

trazadone and remeron are antidepressant used for –

A

sleep aides

52
Q

two marketed drugs that are COMT inhibitors

A

entacapone and tolcapone

53
Q

function of COMT inhibitors in Parkinson patients?

A

prevent l-Dopa metabolism to dopamine (as well as inhibit EPI/levonordefrin metabolism)

Systems 1 (22 decks)

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