Crohn's Disease Flashcards

1
Q

Aetiologies?

A

Genetic vs Environmental triggers

Largely unknown

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Epidemiology?

A

Males = Females

Peak ages 20-40 and 60+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Pathology?

A

Chronic inflammation of anywhere in the GI tract due to prolonged activation of the mucosal immune system vs normal gut flora

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Signs and Symptoms?

A

Depend on location, e.g. diarrhoea, abdominal pain, weight loss, malaise, anorexia, N+V, fever
Malabsorption, mouth ulceration, perianal symptoms, clubbing, erythema nodosum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Investigations and Findings?

A

Colonoscopy + biopsy - Skip lesions, non-caseating granulomas
FBC - decreased Hb
Biochem - increased ESR, decreased albumin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Management?

A

Mild: steroids, progressively lowering dose
Severe: hospital –> IV fluids, high dose steroids, biologics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Complications?

A

Haemorrhage
Perforation
Toxic dilation
Colonic cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly