CPP 1 Ondansetron

Question 1

Ondansetron

Primary emergency indications

Answer 1

All undifferentiated nausea and vomiting

Question 2

Ondansetron

Contraindications

Answer 2

Concurrent
apomorphine use

Question 3

Ondansetron

Precautions

Answer 3

a) Liver disease - must not exceed 8mg/per day,
b) Long QT syndrome,
c) Pregnancy.

• See CPP’s for 5 more.

Question 4

Ondansetron

Key timings
Oral (ODT) wafers

Answer 4

Oral Wafer (ODT).
Onset = 2min
Peak = 20min
Duration = 2hrs

IV.
Onset = 5min,
Peak = 10min,
Duration = 2.5 - 6hrs.

Question 5

Ondansetron

Presentations

Answer 5

a) Wafer/Tablet containing 4mg or 8mg

b) 8mg in 4mL glass ampoule

Question 6

Apomorphine

Answer 6

A medication that treats “off” episodes in Parkinson’s.

It mimics the action of dopamine. Dopamine acts as neurotransmitter/messenger.

Dopamine is also one of the ways your brain controls your movements — low levels of dopamine in certain areas of the brain causes Parkinson’s disease.

Question 7

Long QT Syndrome (LQTS)

Give a brief definition.

Answer 7

LQTS is a condition that affects repolarization (relaxation) of the ventricles.

This leads to an increased likelihood of arrhythmia.

Arrhythmia (most commonly TdP) can lead to fainting, drowning, seizures, cardiac arrest - sudden death.

Normal QT interval =
.360s to .440s.
LQT = >.480s.

Question 8

Ondansetron

Side effects

Answer 8

1. Headache,
2. Constipation,
3. Fever,
4. Prolonged QTc.