Communication Systems Flashcards
innate immunity
defense immediately upon infection
adaptive immunity
molecular recognition and response
difference between innate and adaptive
Adaptive is acquired and enhanced by previous exposure. Innate is the same no matter previous exposure.
key cell in adaptive immunity
lymphocytes: type of WBC
types of lymphocytes
B cells and T cells
antigen
any substance that elicits response from B or T cells
antigen receptor
protein on B and T cells where they bind to antigens for recognition
antibody
soluble form of antigen receptor secreted by B cells
How do B cells recognize foreign invaders?
B cell receptors bind to the epitope of the antigen on the pathogen
How do T cells recognize foreign invaders?
T cells receptors bind to antigen fragments presented on surface of a protein called MHC molecule
Major characteristics of the immune system:
- diversity of receptors
- self tolerance
- clonal selection
- immunological memory
What is clonal selection?
an encounter with an antigen selects/dictates which lymphocyte to proliferate
humoral response
B cells eliminate pathogens in blood and lymph
cell-mediated response
T cells destroy infected host cells
helper T cells
send signal to initiate antibody production and activate T cells
cytotoxic T cells
eliminate (lyse) infected cells
plasma cell
antibody factories. antibody-secreting effector cells
What are the antibody-mediated mechanisms for antigen disposal
neutralization
opsonization
pore formation
neutralization
block ability to bind to host cells
opsonization
tag for phagocytosis
pore formation
water rushes in, cell swells and lyses
effector cells
take effect immediately against antigen