Colonic Polyps Flashcards
1
Q
Definition of polyps
A
Abnormal growth of tissue projecting from colonic mucosa
2
Q
Types of polyps?
A
-Adenoma= tubular, villous, tubulovillous, flat, sessile, pedunculated, all ******dysplastic
3
Q
How adenoma becomes adenocarcinoma?
A
Initial mutation with lots of subsequent mutations leading to adenocarcinoma
4
Q
How does colonic polyps occur?
A
Inherited conditions***
5
Q
FAP means?
A
Familial adenomatous polyposis
6
Q
What is FAP?
A
- Adenomas
- Mutations in the APC gene (tumour suppresor)
- V high risk of developing colonic cancer
7
Q
Describe Lynch syndrome?
A
- Adenomas
- Mutation in the DNA mismatch repair gene
- Associated with other cancers as well as colorectal **
8
Q
Signs/symptoms of polyps?
A
- Asymptomatic
- Rectal bleeding -> anaemia
- Mucus in stool
- Abdo pain
- Diarrhoea/constipation
9
Q
Investigations for polyps?
A
10
Q
Complications?
A
- Majority of colonic cancers arise from pre-existing adenomatous polyps
- Transformation of polyp to cancer 3-5 years - need screening
11
Q
Treatment/Management for colonic polyps?
A
