Coagulation Modifier Drugs

Question 1

What does hemostasis mean?

Answer 1

process that stops bleeding

Question 2

What is a thrombus?

Answer 2

a blood clot

Question 3

What is an embolus?

Answer 3

thrombus that moves through blood vessels

Question 4

What is a myocardial infarction?

Answer 4

embolus that lodges in a coronary artery

Question 5

What is a stroke?

Answer 5

when a embolus obstructs a brain vessel

Question 6

What is a pulmonary emboli?

Answer 6

embolus in pulmonary circulation

Question 7

What is a deep vein thrombosis? (DVT)

Answer 7

embolus goes to a vein in the leg

Question 8

What does the coagulation system do?

Answer 8

results in fibrin a clot-forming substance

Question 9

What does the fibrinolytic system do?

Answer 9

initiates the breakdown of clots

Question 10

What is fibrinolysis?

Answer 10

when a formed thrombi is lysed (breakdown)

Question 11

What happens to a person who has hemophilia?

Answer 11

the natural coagulation and hemostasis factors are limited or absent, this is a genetic disorder

Question 12

What can happen to someone who has hemophilia?

Answer 12

they can bleed to death

Question 13

What do anticoagulants do?

Answer 13

they prevent clot formation

Question 14

What do antiplatelet drugs do?

Answer 14

inhibit platelet aggregation (don’t let platelets get together)

Question 15

What do thrombolytic drugs do?

Answer 15

they lyse (breakdown) clots that already exists in the body

Question 16

What do antifibrinolytic or hemostatic drugs do?

Answer 16

they promote blood coagulation

Question 17

What are the drug names of low molecular weight heparins?

Answer 17

-enoxaparin
-dalteparin

Question 18

What are the names of anticoagulant drugs?

Answer 18

-heparin
-warfarin
(factor Xa anticoagulants)
-fondaparinux
-rivaroxaban

Question 19

What should be monitored while on Heparin?

Answer 19

aPTT every 6 hours

Question 20

What should be monitored while on Warfarin?

Answer 20

PT/INR

Question 21

What is the INR range while on Warfarin?

Answer 21

2-3.5
(if pt is NOT on warfarin, INR should be 1)
< 2 puts pt at risk for clotting, >3.5 puts pt at risk for bleeding

Question 22

What are the drug names of direct thrombin inhibitors

Answer 22

-argatroban
-dabigatran

Question 23

What is the antidote for dabigatran?

Answer 23

Idarucizumab (praxibind)

Question 24

What are the names of antiplatelet

Answer 24

-aspirin
-clopidogrel (plavix)
-prasugrel
-abciximab
-tirofiban
-dipyridamole
-eptifibatide

Question 25

What are the names of thrombolytic drugs?

Answer 25

-alteplase
-reteplase
-tenecteplase

(think ART)

Question 26

What is the name of antifibrinolytic drugs?

Answer 26

desmopressin