Coagulation Modifier Drugs Flashcards
What does hemostasis mean?
process that stops bleeding
What is a thrombus?
a blood clot
What is an embolus?
thrombus that moves through blood vessels
What is a myocardial infarction?
embolus that lodges in a coronary artery
What is a stroke?
when a embolus obstructs a brain vessel
What is a pulmonary emboli?
embolus in pulmonary circulation
What is a deep vein thrombosis? (DVT)
embolus goes to a vein in the leg
What does the coagulation system do?
results in fibrin a clot-forming substance
What does the fibrinolytic system do?
initiates the breakdown of clots
What is fibrinolysis?
when a formed thrombi is lysed (breakdown)
What happens to a person who has hemophilia?
the natural coagulation and hemostasis factors are limited or absent, this is a genetic disorder
What can happen to someone who has hemophilia?
they can bleed to death
What do anticoagulants do?
they prevent clot formation
What do antiplatelet drugs do?
inhibit platelet aggregation (don’t let platelets get together)
What do thrombolytic drugs do?
they lyse (breakdown) clots that already exists in the body
What do antifibrinolytic or hemostatic drugs do?
they promote blood coagulation
What are the drug names of low molecular weight heparins?
-enoxaparin
-dalteparin
What are the names of anticoagulant drugs?
-heparin
-warfarin
(factor Xa anticoagulants)
-fondaparinux
-rivaroxaban
What should be monitored while on Heparin?
aPTT every 6 hours
What should be monitored while on Warfarin?
PT/INR
What is the INR range while on Warfarin?
2-3.5
(if pt is NOT on warfarin, INR should be 1)
< 2 puts pt at risk for clotting, >3.5 puts pt at risk for bleeding
What are the drug names of direct thrombin inhibitors
-argatroban
-dabigatran
What is the antidote for dabigatran?
Idarucizumab (praxibind)
What are the names of antiplatelet
-aspirin
-clopidogrel (plavix)
-prasugrel
-abciximab
-tirofiban
-dipyridamole
-eptifibatide
What are the names of thrombolytic drugs?
-alteplase
-reteplase
-tenecteplase
(think ART)
What is the name of antifibrinolytic drugs?
desmopressin
