Clopidogrel bisulfate

Question 1

Indications - Plavix (clopidogrel bisulfate)

Answer 1

❑ Acute STEMI/NSTEMI ACS

❑ Substitute for ASA if patient cannot take ASA

Question 2

Dosage - Plavix (clopidogrel bisulfate)

Answer 2

Loading dose: 300-600 mg PO
Maintenance dose: of 75 mg PO
Full effects will not develop for several days

Question 3

Contraindications - Plavix (clopidogrel bisulfate)

Answer 3

❑ Hypersensitivity
❑ Active bleeding
❑ Significant liver impairment or cholestatic jaundice
❑ Suspected liver impairment with history of hepatitis; long term ETOH abuse; or a presentation of jaundice
❑ Thrombotic thrombocytopenic purpura
❑ Suspected aortic dissection
❑ When CABG is planned, withhold for 5 days before CABG unless need for revascularization outweighs the risk of significant bleeding